| Item type |
文献 / Documents(1) |
| 公開日 |
2020-03-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pone.0226118 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1371/journal.pone.0226118 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Intraocular pressure elevation after subtenon triamcinolone acetonide injection : Multicentre retrospective cohort study in Japan |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
IOP elevation after STTA |
|
言語 |
en |
| 著者 |
マエダ, ユウキ
イシカワ, ヒロト
ニシカワ, ヒロキ
シミズ, ミホ
木下, 貴正
オギハラ, リエ
キタノ, シゲヒコ
山中, 千尋
三田村, 佳典
スギモト, マサヒコ
コンドウ, ミネオ
タカムラ, ヨシヒロ
オガタ, ナホコ
イケダ, トモヒロ
ゴミ, フミ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose
To evaluate real-world evidence for intraocular pressure (IOP) elevation after subtenon triamcinolone acetonide injection (STTA) in 1252 Japanese patients (1406 eyes) in the Japan Clinical REtina STudy group (J-CREST).
Methods
This was a multicentre retrospective study of the medical records of 1252 patients (676 men (758 eyes); mean age: 63.8 ± 12.9 years) who received STTA in participating centres between April 2013 and July 2017.
Results
IOP elevation was observed in 206 eyes (14.7%) and IOP increase ≥ 6 mmHg was found in 328 eyes (23.3%). In total, 106 eyes (7.5%) needed medication and two eyes (0.14%) needed surgical procedures. Younger age, higher baseline IOP, and steroid dose were risk factors associated with IOP elevation. Risk factors associated with IOP increase ≥ 6 mmHg were younger age, lower baseline IOP, steroid dose, and higher incidences of diabetic macular oedema (DME) and uveitis. In contrast, with steroid dose fixed at 20 mg, a lower incidence of DME was a risk factor for increased IOP, suggesting that STTA had dose-dependent effects on IOP increase, especially in patients with DME.
Conclusion
Our real-world evidence from a large sample of Japanese patients who received STTA showed that the incidence of IOP elevation after STTA was 14.7%, and was associated with younger age, higher baseline IOP, and steroid dose. Thus, IOP should be monitored, especially in patients with younger age, higher baseline IOP, and higher incidences of DME and uveitis. |
|
言語 |
en |
| 書誌情報 |
en : PLOS ONE
巻 14,
号 12,
p. e0226118,
発行日 2019-12-05
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2019 Maeda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
361866 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
pone_14_12_e0226118.pdf (545 KB)
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