| Item type |
文献 / Documents(1) |
| 公開日 |
2020-03-24 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1186/s12888-017-1201-x |
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言語 |
ja |
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|
関連名称 |
10.1186/s12888-017-1201-x |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Increased amygdala reactivity following early life stress : a potential resilience enhancer role |
|
言語 |
en |
| 著者 |
山本, 哲也
トキ, シゲル
Siegle, Greg J.
タカムラ, マサヒロ
タカイシ, ヨシユキ
ヨシムラ, シンペイ
オカダ, ゴウ
マツモト, トモヤ
ナカオ, タカシ
ムラナカ, ヒロユキ
カセダ, ユミコ
ムラカミ, ツネジ
オカモト, ヤスマサ
ヤマワキ, シゲト
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults.
Methods: Twenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS.
Results: Mood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall.
Conclusions: Increased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Early life stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Amygdala reactivity |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fMRI |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Resilience |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Depression |
| 書誌情報 |
en : BMC Psychiatry
巻 17,
p. 27,
発行日 2017-01-18
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1471244X |
| 出版者 |
|
|
出版者 |
BioMed Central |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
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|
識別子 |
344682 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
BMCP_17_27.pdf (1.24 MB)
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