| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2020-03-12 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1111/j.1349-7006.1992.tb02722.x |
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関連名称 |
10.1111/j.1349-7006.1992.tb02722.x |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
ras Mutations in Endocrine Tumors : Mutation Detection by Polymerase Chain Reaction‐Single Strand Conformation Polymorphism |
| 著者 |
吉本, 勝彦
イワハナ, ヒロユキ
フクダ, アユミ
佐野, 壽昭
カツラギ, キヨノリ
キノシタ, モリトシ
齋藤, 史郎
板倉, 光夫
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| 抄録 |
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内容記述 |
To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction‐single strand conformation polymorphism (PCR‐SSCP) analysis. Mutations of the H‐, K‐, N‐ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained mutated N‐ras codon 61, and one contained the mutated H‐ras codon 61. One of the 19 pheochromocytomas revealed mutation of the H‐ras codon 13. No mutations of the ras gene were detected in pituitary adenomas, parathyroid tumors, thyroid cancers, endocrine pancreatic tumors, and adrenocortical tumors. Based on these findings we conclude that activation of the ras gene may play a role in the tumorigenesis of a limited number of thyroid follicular adenomas and pheochromocytomas, and that mutation of the ras gene is not frequent in other human endocrine tumors. |
| キーワード |
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主題 |
ras Gene |
| キーワード |
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主題 |
Missense mutation |
| キーワード |
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主題 |
Thyroid follicular adenoma |
| キーワード |
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主題 |
Pheochromocytoma |
| 書誌情報 |
en : Japanese Journal of Cancer Research
巻 83,
号 10,
p. 1057-1062,
発行日 1992-10
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| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00690844 |
| 出版者 |
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出版者 |
Japanese Cancer Association |
| 出版者 |
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出版者 |
John Wiley & Sons |
| EID |
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識別子 |
71356 |
| 言語 |
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言語 |
eng |
jjcr_83_10_1057.pdf (384 KB)
