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Facilitatory effect of insulin treatment on hepatocellular carcinoma development in diabetes
https://tokushima-u.repo.nii.ac.jp/records/2007333
https://tokushima-u.repo.nii.ac.jp/records/20073336bfe8bba-effe-4364-80b3-440ef8e9bcab
| 名前 / ファイル | ライセンス | アクション |
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BMCRN_10_478.pdf (1.71 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||||||||||
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| 公開日 | 2020-03-26 | |||||||||||||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1186/s13104-017-2783-6 | |||||||||||||||||||||||||||||||||||||||||
| 関連名称 | 10.1186/s13104-017-2783-6 | |||||||||||||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||||||||
| タイトル | Facilitatory effect of insulin treatment on hepatocellular carcinoma development in diabetes | |||||||||||||||||||||||||||||||||||||||||
| 著者 |
ババ, ハヤト
× ババ, ハヤト
× クラノ, マコト
× ニシダ, タケシ
× ハッタ, ヒデキ
× ホカオ, リョウジ
× 常山, 幸一
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| 内容記述 | Background: To evaluate the effect of insulin treatment on the incidence and/or severity of hepatocellular carcinoma (HCC) in a mouse model of HCC based on diabetes. Methods: We recently reported that neonatal streptozotocin (STZ) treatment causes type 1 diabetes and subsequent HCC in ddY, Institute for Animal Reproduction (DIAR) mice. Newborn male DIAR mice were divided into three groups based on STZ and insulin (INS) treatment. STZ was subcutaneously injected (60 mg/g) into the STZ-treated group (DIAR-nSTZ mice, N = 13) and the STZ/insulin-treated group (DIAR-nSTZ/INS mice, N = 20). A physiologic solution was injected into the control group (DIAR-control mice, N = 8) 1.5 days after birth. Insulin was subcutaneously injected into the DIAR-nSTZ/INS mice according to the following protocol: 2 IU/day at 4–5 weeks of age, 3 IU/day at 5–7 weeks of age, and 4 IU/day at 7–12 weeks of age. All mice were fed a normal diet and were subjected to physiological and histopathological assessments at 12 weeks of age. Results: DIAR-nSTZ mice had significantly lower body weight and higher blood glucose levels than DIAR-control mice, whereas no significant differences were observed between DIAR-nSTZ/INS mice and control mice. At 12 weeks of age, lower weight of paratesticular fat and higher levels of total cholesterol, triglyceride, and free fatty acids were observed in DIAR-nSTZ mice compared to DIAR-control mice, whereas there were no significant differences between DIAR-nSTZ/INS mice and DIAR-control mice. In the livers of DIAR-nSTZ mice, HCC was observed in 15% of cases, and dysplastic nodules were observed in 77% of cases. In the livers of DIAR-nSTZ/INS mice, HCC was observed in 39% of cases and dysplastic nodules were observed in 61% of cases (p = 0.011). Moreover, the average tumor size was significantly larger in STZ/INS-treated mice than in STZ-treated mice. Immunohistochemical analysis demonstrated that the expression of ERK1/2, downstream substrates of insulin signaling that activate cell proliferation, was significantly higher in STZ/INS-treated mice compared to STZ-treated mice. Conclusions: Insulin treatment promoted, rather than inhibited, the progression of liver carcinogenesis in DIAR-nSTZ mice. Hyperinsulinemia rather than hyperglycemia can accelerate the progression of HCC via insulin signaling. |
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| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Diabetes mellitus | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Hepatocellular carcinoma | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Insulin | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Hyperinsulinemia | |||||||||||||||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||||||||||||||
| 主題 | Hyperglycemia | |||||||||||||||||||||||||||||||||||||||||
| 書誌情報 |
en : BMC Research Notes 巻 10, p. 478, 発行日 2017-09-13 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||||||||
| 収録物識別子 | 17560500 | |||||||||||||||||||||||||||||||||||||||||
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| 出版者 | BioMed Central | |||||||||||||||||||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||||||||||
| 権利情報 | © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||||||||||||||||||||||||||||||||||||||
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| 識別子 | 333660 | |||||||||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||||||||
