| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.2169/internalmedicine.0092-17 |
|
|
関連名称 |
10.2169/internalmedicine.0092-17 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma |
| 著者 |
アカシ, モモコ
タジリ, カズト
ワダ, アキノリ
常山, 幸一
カワイ, ケンゴ
ヤスムラ, サトシ
ミネムラ, マサミ
タカハラ, テルミ
スギヤマ, トシロウ
|
| 抄録 |
|
|
内容記述 |
A 68-year-old woman with liver dysfunction was diagnosed with nonalcoholic steatohepatitis (NASH) stage 1. Three years later, she showed massive ascites and jaundice. A trans-jugular liver biopsy confirmed advanced cirrhosis, suggesting that her liver fibrosis had progressed rapidly. At the same time, she was diagnosed with multiple myeloma (MM). In this case, the plasma levels of osteopontin (OPN), a proinflammatory cytokine that promotes liver fibrosis progression through the hedgehog pathway and is increased in patients with MM, were increased. This increased OPN expression was accompanied by the upregulation of the hedgehog pathway in this patient, suggesting that the MM-associated increase in OPN had promoted the progression of liver fibrosis through the hedgehog pathway. The progression of liver fibrosis should be monitored in patients with NASH if other diseases, such as MM, are present. |
| キーワード |
|
|
主題 |
non-alcoholic steatohepatitis |
| キーワード |
|
|
主題 |
multiple myeloma |
| キーワード |
|
|
主題 |
osteopontin |
| キーワード |
|
|
主題 |
hedgehog pathway |
| 書誌情報 |
en : Internal Medicine
巻 57,
号 14,
p. 2013-2018,
発行日 2018-07-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13497235 |
| 出版者 |
|
|
出版者 |
The Japanese Society of Internal Medicine |
| 権利情報 |
|
|
権利情報 |
The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
338386 |
| 言語 |
|
|
言語 |
eng |
internalmedicine_57_14_2013.pdf (1.49 MB)
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