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Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr
https://tokushima-u.repo.nii.ac.jp/records/2007370
https://tokushima-u.repo.nii.ac.jp/records/20073707cba792c-8370-483d-871f-5907a689f4bc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fmicb_7_1655.pdf (1.68 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2020-11-19 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3389/fmicb.2016.01655 | |||||||||||||||||||||||
| 関連名称 | 10.3389/fmicb.2016.01655 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr | |||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||
| その他のタイトル | Phylogenetic Insights into RT and Vpx/Vpr | |||||||||||||||||||||||
| 著者 |
サカイ, ヨウスケ
× サカイ, ヨウスケ
× 土肥, 直哉× 宮﨑, 恭行× 足立, 昭夫
WEKO
1594
× 野間口, 雅子
WEKO
246
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| 内容記述 | The efficiency of reverse transcription to synthesize viral DNA in infected cells greatly influences replication kinetics of retroviruses. However, viral replication in non-dividing cells such as resting T cells and terminally differentiated macrophages is potently and kinetically restricted by a host antiviral factor designated SAMHD1 (sterile alpha motif and HD-domain containing protein 1). SAMHD1 reduces cellular deoxynucleoside triphosphate (dNTP) pools and affects viral reverse transcription step. Human immunodeficiency virus type 2 (HIV-2) and some simian immunodeficiency viruses (SIVs) have Vpx or Vpr to efficiently degrade SAMHD1. Interestingly, the reverse transcriptase (RT) derived from HIV-1 that encodes no anti-SAMHD1 proteins has been previously demonstrated to uniquely exhibit a high enzymatic activity. It is thus not irrational to assume that some viruses may have acquired or lost the specific RT property to better adapt themselves to the low dNTP environments confronted in non-dividing cells. This adaptation process may probably be correlated with the SAMHD1-antagonizing ability by viruses. In this report, we asked whether such adaptive events can be inferable from Vpx/Vpr and RT phylogenetic trees overlaid with SAMHD1-degrading capacity of Vpx/Vpr and with kinetic characteristics of RT. Resultant two trees showed substantially similar clustering patterns, and therefore suggested that the properties of RT and Vpx/Vpr can be linked. In other words, HIV/SIVs may possess their own RT proteins to adequately react to various dNTP circumstances in target cells. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | HIV | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | SIV | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Vpx | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | Vpr | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | RT | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | SAMHD1 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | dNTP | |||||||||||||||||||||||
| 書誌情報 |
en : Frontiers in Microbiology 巻 7, p. 1655, 発行日 2016-10-18 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 1664302X | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Frontiers Media S.A. | |||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||
| 権利情報 | Copyright ©2016 Sakai, Doi, Miyazaki, Adachi and Nomaguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 328500 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
