| Item type |
文献 / Documents(1) |
| 公開日 |
2020-04-23 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.nut.2019.110694 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1016/j.nut.2019.110694 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
High-fat diets provoke phosphorus absorption from the small intestine in rats |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Effect of high-fat diet on phosphorus absorption |
|
言語 |
en |
| 著者 |
カワモト, ケイスケ
サクマ, マサエ
タナカ, サラサ
増田, 真志
ナカオ ムラオカ, マリ
ニイダ, ユウキ
ナカマツ, ユリノ
伊藤, 美紀子
竹谷, 豊
新井, 英一
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objective: Dietary carbohydrate/fat ratio may affect phosphorus metabolism because both calcium and phosphorus are regulated by similar metabolic mechanisms, and a high-fat diet (HF) induces deleterious effects on the absorption of dietary calcium. We hypothesized that the HF induces an increase in phosphorus absorption; therefore, this study aimed to evaluate the effects of differences in the quantity and quality of dietary fat on phosphorus metabolism over the short and long term.
Research Methods & Procedures: Eighteen 8-week-old Sprague-Dawley male rats were fed an isocaloric diet containing varied carbohydrate/fat energy ratio and sources of fat (control diet [Control], HF, and high saturated-fat diet [HF-SFA]). At 3 days and 7 weeks after the allocation and initiation of the test diets, feces and urine were collected and used for phosphorus and calcium measurement.
Results: The fecal phosphorous concentration (F-Pi) was lower in the HF-SFA group than in the other two groups; however, the urine phosphorus concentration (U-Pi) was significantly higher in the HF-SFA group than the other two groups when the rats were fed over the short (p<0.01) and long term (p<0.01 vs Control group, p<0.05 vs HF group). There were no significant differences in type-IIa sodium-phosphate cotransporter (NaPi-2a) and type-IIc sodium-phosphate cotransporter (NaPi-2c) mRNA expression, which are renal phosphate transport-related genes; however, the expression of type-IIb sodium-phosphate cotransporter (NaPi-2b) and type-III sodium-phosphate cotransporter (Pit-1) mRNA in the duodenum was higher in the HF and HF-SFA groups than in the Control group (p<0.05), although there were no significant differences in these in the jejunum.
Conclusions: Our results indicated that HF, particularly HF-SFA, increases intestinal phosphate absorption compared with Control. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Serum phosphorus levels |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Calcium |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dietary fat |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Saturated fat |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
duodenum |
| 書誌情報 |
en : Nutrition
巻 72,
p. 110694,
発行日 2019-12-06
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
08999007 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10745727 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11535297 |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
363851 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
nut_72_110694.pdf (755 KB)
