| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fmicb.2017.00188 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fmicb.2017.00188 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
TC83 Sequelae |
|
言語 |
en |
| 著者 |
Ronca, Shannon E.
Smith, Jeanon
駒, 貴明
Miller, Magda M.
Yun, Nadezhda
Dineley, Kelly T.
Paessler, Slobodan
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival to study the development of these long-term neurological complications. Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm. Prepulse inhibition is a robust operational measure of sensorimotor gating, a fundamental form of information processing. Deficits in prepulse inhibition manifest as the inability to filter out extraneous sensory stimuli. Sensory gating is disrupted in schizophrenia and other mental disorders, as well as neurodegenerative diseases. Symptomatic mice developed deficits in prepulse inhibition that lasted through 6 months post infection; these deficits were absent in asymptomatic or mock-infected groups. Accompanying prepulse inhibition deficits, symptomatic animals exhibited thalamus damage as visualized with H&E staining, as well as increased GFAP expression in the posterior complex of the thalamus and dentate gyrus of the hippocampus. These histological changes and increased GFAP expression were absent in the asymptomatic and mock-infected animals, indicating that glial scarring could have contributed to the prepulse inhibition phenotype observed in the symptomatic animals. This model provides a tool to test mechanisms of and treatments for the neurological sequelae of viral encephalitis and begins to delineate potential explanations for the development of such sequelae post infection. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alphavirus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VEEV |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
TC83 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sequelae |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
neurological complications |
| 書誌情報 |
en : Frontiers in Microbiology
巻 8,
p. 188,
発行日 2017-02-07
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1664302X |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Copyright © 2017 Ronca, Smith, Koma, Miller, Yun, Dineley and Paessler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
331125 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fmicb_8_188.pdf (2.89 MB)
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