| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fmicb.2018.01751 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fmicb.2018.01751 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Review of Mammarenavirus Biology and Replication |
|
言語 |
en |
| 著者 |
Hallam, Steven J.
駒, 貴明
マルヤマ, ジュンキ
Paessler, Slobodan
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The family Arenaviridae is divided into three genera: Mammarenavirus, Reptarenavirus, and Hartmanivirus. The Mammarenaviruses contain viruses responsible for causing human hemorrhagic fever diseases including New World viruses Junin, Machupo, Guanarito, Sabia, and Chapare virus and Old World viruses Lassa, and Lujo virus. These two groups of arenaviruses share the same genome organization composed of two ambisense RNA segments. These segments contain four open reading frames that encode for four proteins: the nucleoprotein, glycoprotein precursor, L protein, and Z. Despite their genome similarities, these groups exhibit marked differences in their replication life cycles. This includes differences in attachment, entry, and immune evasion. By understanding the intricacy of replication in each of these viral species we can work to develop counter measures against human diseases. This includes the development of vaccines and antivirals for these emerging viral threats. Currently only the vaccine against Junin virus, Candid#1, is in use as well as Ribavirin for treatment of Lassa Fever. In addition, small molecule inhibitors can be developed to target various aspects of the virus life cycle. In these ways an understanding of the arenavirus replication cycle can be used to alleviate the mortality and morbidity of these infections worldwide. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
arenavirus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
virus replication |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lassa virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
junin virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
viral entry |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
virus immune evasion |
| 書誌情報 |
en : Frontiers in Microbiology
巻 9,
p. 1751,
発行日 2018-08-03
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1664302X |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Copyright © 2018 Hallam, Koma, Maruyama and Paessler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
344869 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fmicb_9_1751.pdf (598 KB)
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