| Item type |
文献 / Documents(1) |
| 公開日 |
2020-06-15 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3389/fphar.2019.01257 |
|
|
関連名称 |
10.3389/fphar.2019.01257 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database |
| タイトル別表記 |
|
|
その他のタイトル |
Drug Repositioning for Cardiac Arrest |
| 著者 |
座間味, 義人
新村, 貴博
コヤマ, トシヒロ
シゲミ, ユウタ
(井澤)石澤, 有紀
モリタ, ミズキ
オオシマ, アヤコ
ハラダ, ケイサク
イマイ, トオル
ハギワラ, ヒロミ
岡田, 直人
合田, 光寛
武智, 研志
中馬, 真幸
コンドウ, ユタカ
土屋, 浩一郎
ヒノツ, シロウ
カノウ, ミツノブ
石澤, 啓介
|
| 抄録 |
|
|
内容記述 |
The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using “TargetMine,” a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Center. Logistic regression analysis was performed, with the explanatory variables being the presence or absence of the administration of those candidate drugs that were administered to ≥10 patients and the objective variable being the “survival discharge.” Adjusted odds ratios for survival discharge were calculated using propensity scores for drugs that significantly improved the proportion of survival discharge; the influence of covariates, such as patient background, medical history, and treatment factors, was excluded by the inverse probability-of-treatment weighted method. Using the search strategy, we extracted 165 drugs with vasodilator activity as candidate drugs. Drugs not approved in Japan, oral medicines, and external medicines were excluded. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three (isosorbide dinitrate, nitroglycerin, and nicardipine) of seven drugs that were administered to ≥10 patients showed significant association with improvement in the proportion of survival discharge. Further analyses using propensity scores revealed that the adjusted odds ratios for survival discharge for patients administered isosorbide dinitrate, nitroglycerin, and nicardipine were 3.35, 5.44, and 4.58, respectively. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients. |
| キーワード |
|
|
主題 |
cardiac arrest |
| キーワード |
|
|
主題 |
drug repositioning |
| キーワード |
|
|
主題 |
claims database |
| キーワード |
|
|
主題 |
drug discovery tool |
| キーワード |
|
|
主題 |
vasodilator |
| 書誌情報 |
en : Frontiers in Pharmacology
巻 10,
p. 1257,
発行日 2019-11-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16639812 |
| 出版者 |
|
|
出版者 |
Frontiers Media SA |
| 権利情報 |
|
|
権利情報 |
Copyright © 2019 Zamami, Niimura, Koyama, Shigemi, Izawa-Ishizawa, Morita, Ohshima, Harada, Imai, Hagiwara, Okada, Goda, Takechi, Chuma, Kondo, Tsuchiya, Hinotsu, Kano and Ishizawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
361105 |
| 言語 |
|
|
言語 |
eng |
fphar_10_1257.pdf (1020 KB)
.png)
