| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3389/fimmu.2018.02196 |
|
|
関連名称 |
10.3389/fimmu.2018.02196 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node |
| タイトル別表記 |
|
|
その他のタイトル |
Lymph Node Stromal Cell Subsets |
| 著者 |
タケウチ, アラタ
オザワ, マドカ
カンダ, ヤスヒロ
コウザイ, ミナ
大東, いずみ
クロサワ, ヨウイチ
Rahman, Md Azizur
カワムラ, トシヒコ
シチダ, ユウト
ウメモト, エイジ
ミヤサカ, マサユキ
Ludewig, Burkhard
高浜, 洋介
ナガサワ, タカシ
カタカイ, トモヤ
|
| 抄録 |
|
|
内容記述 |
The spatiotemporal regulation of immune responses in the lymph node (LN) depends on its sophisticated tissue architecture, consisting of several subcompartments supported by distinct fibroblastic stromal cells (FSCs). However, the intricate details of stromal structures and associated FSC subsets are not fully understood. Using several gene reporter mice, we sought to discover unrecognized stromal structures and FSCs in the LN. The four previously identified FSC subsets in the cortex are clearly distinguished by the expression pattern of reporters including PDGFRb, CCL21-ser, and CXCL12. Herein, we identified a unique FSC subset expressing both CCL21-ser and CXCL12 in the deep cortex periphery (DCP) that is characterized by preferential B cell localization. This subset was clearly different fromCXCL12highLepRhigh FSCs in themedullary cord, which harbors plasma cells. B cell localization in the DCP was controlled chiefly by CCL21-ser and, to a lesser extent, CXCL12. Moreover, the optimal development of the DCP as well as medulla requires B cells. Together, our findings suggest the presence of a unique microenvironment in the cortex-medulla boundary and offer an advanced view of the multi-layered stromal framework constructed by distinct FSC subsets in the LN. |
| キーワード |
|
|
主題 |
chemokines |
| キーワード |
|
|
主題 |
deep cortex |
| キーワード |
|
|
主題 |
fibroblastic stromal cells |
| キーワード |
|
|
主題 |
lymph node |
| キーワード |
|
|
主題 |
medulla |
| キーワード |
|
|
主題 |
subcompartment |
| 書誌情報 |
en : Frontiers in Immunology
巻 9,
p. 2196,
発行日 2018-10-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16643224 |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
| 権利情報 |
|
|
権利情報 |
Copyright © 2018 Takeuchi, Ozawa, Kanda, Kozai, Ohigashi, Kurosawa, Rahman, Kawamura, Shichida, Umemoto, Miyasaka, Ludewig, Takahama, Nagasawa and Katakai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
352962 |
| 言語 |
|
|
言語 |
eng |
fimmu_9_2196.pdf (13.4 MB)
.png)
