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Well-designed dopamine-imprinted polymer interface for selective and quantitative dopamine detection among catecholamines using a potentiometric biosensor
https://tokushima-u.repo.nii.ac.jp/records/2007417
https://tokushima-u.repo.nii.ac.jp/records/200741765531764-9958-492b-9f53-a3e623051150
| 名前 / ファイル | ライセンス | アクション |
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bios_117_810.pdf (2.29 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||
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| 公開日 | 2020-04-30 | |||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bios.2018.07.014 | |||||||||||||||||||
| 関連名称 | 10.1016/j.bios.2018.07.014 | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Well-designed dopamine-imprinted polymer interface for selective and quantitative dopamine detection among catecholamines using a potentiometric biosensor | |||||||||||||||||||
| 著者 |
加治佐, 平
× 加治佐, 平× Li, Wei
× ミチノブ, ツヨシ
× サカタ, トシヤ
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| 抄録 | ||||||||||||||||||||
| 内容記述 | We report a well-designed biointerface enabling the selective and quantitative detection of dopamine (DA) using a potentiometric biosensor. To enhance the detection selectivity of DA, a DA-templated molecularly imprinted polymer (DA–MIP) was synthesized on the extended Au gate electrode of a field-effect transistor (FET) biosensor. For a quantitative DA analysis, the thickness of the DA–MIP was controlled to ca. 60 nm by surface-initiated atom transfer radical polymerization (SI-ATRP). In this process, the DA–MIP was copolymerized with vinylphenylboronic acid (vinyl-PBA), inducing molecular charges at the biointerface of the FET gate electrode. These charges were generated by the diol-binding between PBA and dopamine (a catecholamine), and were directly detected as a change in surface potential. In fact, the surface potential at the gate of the DA–MIP-coated FET responded significantly to DA added at concentrations ranging from 40 nM to μM, whereas that of a non-imprinted polymer (NIP)-coated FET hardly changed over this range. Moreover, by measuring the kinetic parameters and electrochemical properties of well-designed devices with various added catecholamines, we confirmed that the DA–MIP-coated FET biosensor selectively and quantitatively detects DA. | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Catecholamine | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Dopamine | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Molecularly imprinted polymer | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Field-effect transistor | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題 | Surface-initiated atom transfer radical polymerization | |||||||||||||||||||
| 書誌情報 |
en : Biosensors and Bioelectronics 巻 117, p. 810-817, 発行日 2018-07-11 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 09565663 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA10739666 | |||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA1152282X | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||
| 権利情報 | ||||||||||||||||||||
| 権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||
| EID | ||||||||||||||||||||
| 識別子 | 363921 | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
