| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-24 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fnins.2019.00237 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fnins.2019.00237 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Sleep and Neurochemical Modulation by DZNep and GSK-J1 : Potential Link With Histone Methylation Status |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Histone Methylation/Demethylation Inhibition Modulates Sleep |
|
言語 |
en |
| 著者 |
Murillo-Rodríguez, Eric
Arankowsky-Sandoval, Gloria
Barros, Jorge Aparecido
Rocha, Nuno Barbosa
山本, 哲也
Machado, Sérgio
Budde, Henning
Telles-Correia, Diogo
Monteiro, Diogo
Cid, Luis
Veras, André Barciela
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Histone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes. Due to many human diseases have been related to histone methylation/demethylation, several compounds such as 3-deazaneplanocin A (DZNep) or 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid; N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-b-Alanine (GSK-J1), have been designed to inhibit histone methylase or suppress histone demethylase, respectively. In the present study, we investigated the effects on the sleep-wake cycle and sleep-related neurochemical levels after systemic injections of DZNep or GSK-J1 given during the light or dark phase in rats. DZNep dose-dependently (0.1, 1.0, or 10 mg/kg, i.p.) prolonged wakefulness (W) duration while decreased slow wave sleep (SWS) and rapid eye movement sleep (REMS) time spent during the lights-on period with no changes observed in dark phase. In opposite direction, GSK-J1 (0.1, 1.0, or 10 mg/kg, i.p.) injected at the beginning of the lights-on period induced no statistical changes in W, SWS, or REMS whereas if administered at darkness, we found a diminution in W and an enhancement in SWS and REMS. Finally, brain microdialysis experiments in freely moving animals were used to evaluate the effects of DZNep or GSK-J1 treatments on contents of sleep-related neurochemicals. The results showed that DZNep boosted extracellular levels of dopamine, norepinephrine, epinephrine, serotonin, adenosine, and acetylcholine if injected at the beginning of the lights-on period whereas GSK-J1 exerted similar outcomes but when administered at darkness. In summary, DZNep and GSK-J1 may control the sleep-wake cycle and sleep-related neurochemicals through histone methylation/demethylation activity. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adenosine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dopamine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
histone demethylation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
serotonin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sleep |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
wakefulness |
| 書誌情報 |
en : Frontiers in Neuroscience
巻 13,
p. 237,
発行日 2019-03-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1662453X |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Copyright © 2019 Murillo-Rodríguez, Arankowsky-Sandoval, Barros, Rocha, Yamamoto, Machado, Budde, Telles-Correia, Monteiro, Cid and Veras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
358142 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fnins_13_237.pdf (3.95 MB)
.png)
