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Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance
https://tokushima-u.repo.nii.ac.jp/records/2007439
https://tokushima-u.repo.nii.ac.jp/records/2007439defb98e9-e88c-4a8f-99db-979d4c9dc1ac
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
wjd_8_3_97.pdf (1.2 MB)
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| Item type | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2020-11-26 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.4239/wjd.v8.i3.97 | |||||||||||
| 関連名称 | 10.4239/wjd.v8.i3.97 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Cbl-b regulates macrophage activation | |||||||||||
| 著者 |
安倍, 知紀
× 安倍, 知紀× 平坂, 勝也× 二川, 健
WEKO
1586
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| 抄録 | ||||||||||||
| 内容記述 | Aging and overnutrition cause obesity in rodents and humans. It is well-known that obesity causes various diseases by producing insulin resistance (IR). Macrophages infiltrate the adipose tissue (AT) of obese individuals and cause chronic low-level inflammation associated with IR. Macrophage infiltration is regulated by the chemokines that are released from hypertrophied adipocytes and the immune cells in AT. Saturated fatty acids are recognized by toll-like receptor 4 (TLR4) and induce inflammatory responses in AT macrophages (ATMs). The inflammatory cytokines that are released from activated ATMs promote IR in peripheral organs, such as the liver, skeletal muscle and AT. Therefore, ATM activation is a therapeutic target for IR in obesity. The ubiquitin ligase Casitas b-lineage lymphoma-b (Cbl-b) appears to potently suppress macrophage migration and activation. Cbl-b is highly expressed in leukocytes and negatively regulates signals associated with migration and activation. Cbl-b deficiency enhances ATM accumulation and IR in aging- and diet-induced obese mice. Cbl-b inhibits migration-related signals and SFA-induced TLR4 signaling in ATMs. Thus, targeting Cbl-b may be a potential therapeutic strategy to reduce the IR induced by ATM activation. In this review, we summarize the regulatory functions of Cbl-b in ATMs. | |||||||||||
| キーワード | ||||||||||||
| 主題 | Casitas b-lineage lymphoma-b | |||||||||||
| キーワード | ||||||||||||
| 主題 | Insulin resistance | |||||||||||
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| 主題 | Macrophage | |||||||||||
| キーワード | ||||||||||||
| 主題 | Obesity | |||||||||||
| キーワード | ||||||||||||
| 主題 | Toll-like receptor 4 | |||||||||||
| 書誌情報 |
en : World Journal of Diabetes 巻 8, 号 3, p. 97-103, 発行日 2017-03-15 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 19489358 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Baishideng Publishing Group Inc. | |||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | |||||||||||
| EID | ||||||||||||
| 識別子 | 330001 | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
