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Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men
https://tokushima-u.repo.nii.ac.jp/records/2007443
https://tokushima-u.repo.nii.ac.jp/records/2007443840c0a6f-f61f-426e-bc31-8457b6c04ef2
| 名前 / ファイル | ライセンス | アクション |
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cardiab_15_77.pdf (2.45 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||
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| 公開日 | 2020-11-26 | |||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1186/s12933-016-0394-5 | |||||||||||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||||||||||
| 関連名称 | 10.1186/s12933-016-0394-5 | |||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||
| タイトル | Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 著者 |
島袋, 充生
× 島袋, 充生× ヒガ, ナミオ
× マスザキ, ヒロアキ
× 佐田, 政隆
WEKO
309
× ウエダ, シンイチロウ
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| 抄録 | ||||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||
| 内容記述 | Background: Impaired vasoreactivity is often observed in subjects with metabolic syndrome, a condition that includes the presence of a specific cluster of risk factors for obesity and cardiovascular disease. However, hierarchical causes in the impaired vasoreactivity have not been clarified. We evaluated the impact of individual metabolic risk components or its clustering under the condition of insulin resistance on endothelial and smooth muscle cell function. Methods: Vascular reactivity to acetylcholine (Ach), with or without nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA), or sodium nitroprusside (SNP) by forearm venous occlusion plethysmography and insulin sensitivity index (M mg/kg/min) in euglycemic clamp were measured in men without (n = 18, control group) or with (n = 19, metabolic syndrome group) metabolic syndrome. Results: (1) Ach-induced maximal forearm blood flow (maxFBF) was impaired in subjects with metabolic syndrome. In particular, the NOS-dependent component of Ach-induced maxFBF was selectively decreased, while the NOS-independent component remained relatively unchanged. (2) Ach-induced maxFBF and ΔAch-induced maxFBF with L-NMMA were correlated with waist circumference, glucose, and triglycerides, and most strongly correlated with visceral fat area, adiponectin, and M. (3) Multivariate regression analysis indicated that individual metabolic risk components explained Ach-induced maxFBF by 4–21 %. Clustering of all metabolic risk components increased this to 35 %, and the presence of metabolic syndrome explained 30 %, indicating that defining metabolic syndrome can effectively predict impairment of endothelial dysfunction. Conclusions: Endothelial dysfunction was correlated with individual metabolic risk components, but more strongly with clustering of the components under a condition with low insulin sensitivity. We suggest that in subjects with metabolic syndrome, endothelial function is impaired by multiple cardiovascular risk factors exclusively when under the condition of insulin insensitivity and also that defining metabolic syndrome can effectively predict impairment of endothelial dysfunction. |
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| 言語 | en | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||||||
| 主題 | Obesity | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||||||
| 主題 | Metabolic syndrome | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||||||
| 主題 | Endothelial function | |||||||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||||||||
| 主題 | Insulin resistance | |||||||||||||||||||||||||||||
| 書誌情報 |
en : Cardiovascular Diabetology 巻 15, p. 77, 発行日 2016-05-17 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||
| 収録物識別子 | 14752840 | |||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
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| 出版者 | BioMed Central | |||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||
| 権利情報 | © 2016 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||||||||||||||||||||||||||
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| 識別子 | 312429 | |||||||||||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||
