| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-30 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1186/s12948-017-0061-8 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1186/s12948-017-0061-8 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy |
|
言語 |
en |
| 著者 |
ナガオ, ミズホ
Borres, Magnus P.
杉本, 真弓
Petersson, Carl Johan
ナカヤマ, サトシ
クワバラ, ユウ
マスダ, サワコ
Dykiel, Patrik
フジサワ, タカオ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.
Methods: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals’ outcome on asthma inception.
Results: At 2 years of follow-up, physician-diagnosed asthma was 19.7% (n = 49) and asthma diagnosed any time was 24% (n = 67). History of persistent cough and asthma of father, combination of milk- and wheat-allergy symptoms and dual sensitization to house dust mite and Japanese cedar were independent risk factors for asthma. Sensitization to dog was the most prevalent inhalant allergen at entry. Asthma children had a higher proportion of sensitization to dog, cat and horse allergens at entry compared with non-asthma children. Being sensitized to both food, house dust mite and pet allergens was strongly associated with asthma (p = 0.0006). Component resolved diagnosis for dog and cat allergens showed that IgE antibodies to Can f 1 and Fel d 1 was common even at very young age.
Conclusions: Early sensitization to inhalant allergens increases the risk of developing asthma as well as having milk and wheat allergy symptoms. Sensitization to dog, was common at an early age despite dog ownership. Sensitization to secretoglobin and lipocalins and less to serum albumins explained the pet sensitization. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Asthma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Allergy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Children |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Molecular allergy diagnostics |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Pet allergen components |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Component resolved diagnosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Food allergy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Secretoglobin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lipocalin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sensitization |
| 書誌情報 |
en : Clinical and Molecular Allergy
巻 15,
p. 4,
発行日 2017-03-03
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14767961 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
BioMed Central |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
|
|
識別子 |
326786 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
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