Item type |
文献 / Documents(1) |
公開日 |
2020-05-01 |
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アクセス権 |
open access |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版社版DOI |
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関連識別子 |
https://doi.org/10.1186/s12876-020-01194-2 |
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関連名称 |
10.1186/s12876-020-01194-2 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
タイトル |
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タイトル |
Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis |
著者 |
タカイ, アツコ
キクチ, ケンタロウ
(市村)清水, 真祐子
常山, 幸一
モリトキ, ユウキ
マツモト, コウタロウ
ツナシマ, ヒロミチ
オンダ, タケシ
クニヨシ, ノリユキ
ナリヤマ, トモユキ
オオヤツ, ショウ
クボタ, ジュリ
ナグモ, コズエ
サトウ, シンペイ
ハラ, マスミ
ミヤカワ, ヒロシ
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抄録 |
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内容記述 |
Background: Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Within the spectrum of NAFLD, non-alcoholic steatohepatitis (NASH) in combination with hepatic inflammation and fibrosis can lead to liver cirrhosis and hepatocellular carcinoma. Dysbiosis was reported to contribute to NASH pathogenesis. This study aimed to determine the effects of fructo-oligosaccharides (FOS) on steatohepatitis and visceral adiposity in an obese mouse model of NASH. Methods: Twelve newborn C57BL/6 J male mice were subcutaneously injected with monosodium glutamate (MSG) to induce obesity on a conventional diet. Six mice were also administered 5% FOS via drinking water from 10 weeks of age. At 18 weeks, histological characteristics of the liver and epididymal fat were compared between the groups. Hepatic mRNA expression of lipid metabolism enzymes and SCFA in feces and sera were measured. Results: Hepatic steatosis, inflammatory cell infiltration, and hepatocyte ballooning in the liver and increased hepatic mRNA expression of fatty acid synthase and glycerol-3-phosphate acyltransferase were observed in the MSG-treated mice. FOS treatment improved the liver pathology and blunted the increases in the mRNA expression levels of lipid metabolism enzymes. In addition, FOS inhibited adipocyte enlargement and formation of crown-like structures and reduced the M1 macrophage frequency in the epididymal fat of the MSG mice (39.4% ± 3.0% vs. 22.8% ± 0.7%; P = 0.001). FOS increased not only the fecal concentrations of n-butyric acid (0.04 ± 0.01 vs. 0.38 ± 0.14 mg/g, P = 0.02), propionic acid (0.09 ± 0.03 vs. 0.42 ± 0.16 mg/g, P = 0.02), and acetic acid (0.65 ± 0.16 vs. 1.48 ± 0.29 mg/g, P = 0.03) but also the serum concentration of propionic acid (3.9 ± 0.5 vs. 8.2 ± 0.5 μmol/L, P = 0.001). Conclusions: FOS ameliorates steatohepatitis, visceral adiposity, and chronic inflammation by increasing SCFA production. |
キーワード |
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主題 |
Fructo-oligosaccharides |
キーワード |
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主題 |
Monosodium glutamate |
キーワード |
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主題 |
Non-alcoholic fatty liver disease |
キーワード |
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主題 |
Non-alcoholic steatohepatitis |
キーワード |
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主題 |
Short-chain fatty acids |
書誌情報 |
en : BMC Gastroenterology
巻 20,
p. 46,
発行日 2020-02-27
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収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1471230X |
収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12034934 |
出版者 |
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出版者 |
Springer Nature |
出版者 |
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出版者 |
BioMed Central |
権利情報 |
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権利情報 |
© The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
EID |
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識別子 |
363239 |
言語 |
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言語 |
eng |