| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-07 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1186/s12931-017-0654-2 |
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関連名称 |
10.1186/s12931-017-0654-2 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity |
| 著者 |
佐藤, 正大
シノハラ, シンタロウ
ハヤシ, シンヤ
森住, 俊
アベ, シュウイチ
オカザキ, ヒロヤス
Chen, Yanjuan
後東, 久嗣
青野, 純典
小川, 博久
小山, 壱也
ニシムラ, ハルカ
河野, 弘
豊田, 優子
上原, 久典
西岡, 安彦
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| 抄録 |
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内容記述 |
Background: Nintedanib, a tyrosine kinase inhibitor that is specific for platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR), has recently been approved for idiopathic pulmonary fibrosis. Fibrocytes are bone marrow-derived progenitor cells that produce growth factors and contribute to fibrogenesis in the lungs. However, the effects of nintedanib on the functions of fibrocytes remain unclear.
Methods: Human monocytes were isolated from the peripheral blood of healthy volunteers. The expression of growth factors and their receptors in fibrocytes was analyzed using ELISA and Western blotting. The effects of nintedanib on the ability of fibrocytes to stimulate lung fibroblasts were examined in terms of their proliferation. The direct effects of nintedanib on the differentiation and migration of fibrocytes were also assessed. We investigated whether nintedanib affected the accumulation of fibrocytes in mouse lungs treated with bleomycin.
Results: Human fibrocytes produced PDGF, FGF2, and VEGF-A. Nintedanib and specific inhibitors for each growth factor receptor significantly inhibited the proliferation of lung fibroblasts stimulated by the supernatant of fibrocytes. Nintedanib inhibited the migration and differentiation of fibrocytes induced by growth factors in vitro. The number of fibrocytes in the bleomycin-induced lung fibrosis model was reduced by the administration of nintedanib, and this was associated with anti-fibrotic effects.
Conclusions: These results support the role of fibrocytes as producers of and responders to growth factors, and suggest that the anti-fibrotic effects of nintedanib are at least partly mediated by suppression of fibrocyte function. |
| キーワード |
|
|
主題 |
Fibrocytes |
| キーワード |
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|
主題 |
Nintedanib |
| キーワード |
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|
主題 |
Pulmonary fibrosis |
| 書誌情報 |
en : Respiratory Research
巻 18,
p. 172,
発行日 2017-09-15
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1465993X |
| 出版者 |
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出版者 |
Springer Nature |
| 出版者 |
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出版者 |
BioMed Central |
| 権利情報 |
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|
権利情報 |
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
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|
識別子 |
338651 |
| 言語 |
|
|
言語 |
eng |
respres_18_172.pdf (2.37 MB)
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