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Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction
https://tokushima-u.repo.nii.ac.jp/records/2007486
https://tokushima-u.repo.nii.ac.jp/records/2007486bb2154ce-00eb-4cf4-b56d-c79cb9f008e0
| 名前 / ファイル | ライセンス | アクション |
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ccs_16_54.pdf (2.68 MB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||||||||||
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| 公開日 | 2020-12-07 | |||||||||||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||||||||||
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| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||
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| 関連識別子 | https://doi.org/10.1186/s12964-018-0262-x | |||||||||||||||||||||||||||||||
| 関連名称 | 10.1186/s12964-018-0262-x | |||||||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||
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| タイトル | Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction | |||||||||||||||||||||||||||||||
| 著者 |
Feng, Rui
× Feng, Rui
× 森根, 裕二
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× 池本, 哲也
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265
× 居村, 暁× 岩橋, 衆一× 齋藤, 裕
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702
× 島田, 光生
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1253
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| 内容記述 | Background: The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)-Like 2 (Nrf2) not only modulates the angiogenesis but also plays the anti-inflammatory role through inhibiting pro-inflammatory cytokines expression; however, the role of Nrf2 in the cancer cell and macrophages interaction is not clear. Methods: Hepatocellular carcinoma cells (Hep G2 and Huh 7) and pancreatic cancer cells (SUIT2 and Panc-1) were co-cultured with monocytes cells (THP-1) or peripheral blood monocytes derived macrophages, then the phenotype changes of macrophages and epithelial-mesenchymal transition of cancer cells were detected. Also, the role of Nrf2 in cancer cells and macrophages interaction were investigated. Results: In this study, we found that cancer cells could induce an M2-like macrophage characterized by up-regulation of CD163 and Arg1, and down-regulation of IL-1b and IL-6 through Nrf2 activation. Also, Nrf2 activation of macrophages promoted VEGF expression. The Nrf2 activation of macrophages correlated with the reactive oxygen species induced by cancer cells derived lactate. Cancer cells educated macrophages could activate Nrf2 of the cancer cells, in turn, to increase cancer cells epithelial-mesenchymal transition (EMT) through paracrine VEGF. These findings suggested that Nrf2 played the important role in the cancer cells and macrophages interaction. Conclusions: Macrophage Nrf2 activation by cancer cell-derived lactate skews macrophages polarization towards an M2-like phenotype and educated macrophages activate Nrf2 of the cancer cells to promote EMT of cancer cells. This study provides a new understanding of the role of Nrf2 in the cancer cell and TAM interaction and suggests a potential therapeutic target. |
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| キーワード | ||||||||||||||||||||||||||||||||
| 主題 | Nuclear factor (erythroid-derived 2)-like 2 | |||||||||||||||||||||||||||||||
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| 主題 | Tumor-associated macrophage | |||||||||||||||||||||||||||||||
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| 主題 | Hepatocellular carcinoma | |||||||||||||||||||||||||||||||
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| 主題 | Pancreatic cancer | |||||||||||||||||||||||||||||||
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| 主題 | Epithelial-mesenchymal transition | |||||||||||||||||||||||||||||||
| 書誌情報 |
en : Cell Communication and Signaling 巻 16, p. 54, 発行日 2018-09-04 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 1478811X | |||||||||||||||||||||||||||||||
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| 出版者 | Springer Nature | |||||||||||||||||||||||||||||||
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| 出版者 | BioMed Central | |||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||
| 権利情報 | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||||||||||||||||||||||||||||
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| 識別子 | 351465 | |||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||
