| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-07 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1186/s13601-018-0233-8 |
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関連名称 |
10.1186/s13601-018-0233-8 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy : a multicenter, investigator‑blinded, randomized, parallel group controlled trial (PACI Study) : protocol for a randomized controlled trial |
| 著者 |
ヤマモト ハナダ, キワコ
コバヤシ, トオル
Williams, Hywel C.
ミカミ, マサシ
サイトウ アベ, マヤコ
モリタ, クミコ
ナツメ, オサム
サトウ, ミオリ
イワマ, モトコ
ミヤジ, ユミコ
ミヤタ, マキコ
イナガキ, シンイチロウ
フクイエ, タツキ
ナリタ, マサミ
ナカヤマ, ショウジ
木戸, 博
サイトウ, ヒロヒサ
オオヤ, ユキヒロ
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| 抄録 |
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内容記述 |
Background: Atopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rhinitis. Recent evidence suggests that sensitization to foods may occur through a defective skin barrier which is common in atopic dermatitis in early life. We hypothesize that therapeutic aggressive intervention to treat new onset atopic dermatitis may prevent the development of later allergen sensitization, and associated food allergy, asthma, and allergic rhinitis.
Methods: This study is a multi-center, pragmatic, two-parallel group, assessor-blind, superiority, individually randomized controlled trial. Atopic dermatitis infants (N = 650) 7–13 weeks old who develop an itchy rash within the previous 28 days are randomly assigned to the aggressive treatment or the conventional treatment in a 1:1 ratio. The primary outcome is oral food challenge-proven IgE-mediated hen’s egg allergy at the age of 28 weeks.
Discussion: This is a novel pragmatic RCT study to examine the efficacy of early aggressive treatment for atopic dermatitis to prevent later food allergy. If our hypothesis is correct, we hope that such a strategy might impact on disease prevention in countries where food allergy is common, and that our results might reduce the frequency and associated costs of all food allergies as well as hens egg food allergy. Long-term follow and other similar studies will help to determine whether such a strategy will reduce the burden of other allergic diseases such as asthma and allergic rhinitis. |
| キーワード |
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|
主題 |
Atopic dermatitis |
| キーワード |
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|
主題 |
Prevention |
| キーワード |
|
|
主題 |
Food allergy |
| キーワード |
|
|
主題 |
Infants |
| キーワード |
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|
主題 |
Randomized controlled trial |
| 書誌情報 |
en : Clinical and Translational Allergy
巻 8,
p. 47,
発行日 2018-11-23
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20457022 |
| 出版者 |
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出版者 |
Springer Nature |
| 出版者 |
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出版者 |
BioMed Central |
| 権利情報 |
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|
権利情報 |
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
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|
識別子 |
356471 |
| 言語 |
|
|
言語 |
eng |
cta_8_47.pdf (1.15 MB)
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