| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-07 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.2188/jea.JE20160189 |
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関連名称 |
10.2188/jea.JE20160189 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men |
| タイトル別表記 |
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その他のタイトル |
Alcohol Intake and Serum Lipids–Genetic Modification |
| 著者 |
ササカベ, タエ
ワカイ, ケンジ
カワイ, サヨ
ヒシダ, アサヒ
ナイトウ, マリコ
スズキ, サダオ
Nindita, Yora
有澤, 孝吉
キタ, ヨシクニ
ハラ, メグミ
クリヤマ, ナガト
ヒラタ, アキエ
ミカミ, ハルオ
オゼ, イサオ
クボ, ミチアキ
タナカ, ヒデオ
ハマジマ, ノブユキ
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| 抄録 |
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内容記述 |
Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated.
Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study.
Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated.
Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men. |
| キーワード |
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|
主題 |
ALDH2 |
| キーワード |
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主題 |
ADH1B |
| キーワード |
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主題 |
alcohol intake |
| キーワード |
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主題 |
lipid profile |
| 書誌情報 |
en : Journal of Epidemiology
巻 28,
号 4,
p. 185-193,
発行日 2017-11-25
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13499092 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09175040 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10952696 |
| 出版者 |
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出版者 |
Japan Epidemiological Association |
| 権利情報 |
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|
権利情報 |
© 2017 Tae Sasakabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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識別子 |
323883 |
| 言語 |
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|
言語 |
eng |
jepide_28_4_185.pdf (666 KB)
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