| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-09 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/cas.14005 |
|
|
関連名称 |
10.1111/cas.14005 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
New era of research on cancer-associated glycosphingolipids |
| 著者 |
フルカワ, コウイチ
オオミ, ユウスケ
オオカワ, ユウキ
Bhuiyan, Robiul H.
Zhang, Pu
タジマ, オリエ
橋本, 登
ハマムラ, カズノリ
フルカワ, ケイコ
|
| 抄録 |
|
|
内容記述 |
Cancer-associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis of their implications in the malignant properties of cancer cells revealed that cancer-associated glycosphingolipids are not only tumor markers, but also functional molecules regulating various signals introduced by membrane microdomains, lipid rafts. In particular, a novel approach, enzyme-mediated activation of radical sources combined with mass spectrometry, has enabled us to clarify the mechanisms by which cancer-associated glycosphingolipids regulate cell signals based on the interaction with membrane molecules and formation of molecular complexes on the cell surface. Novel findings obtained from these approaches are now providing us with insights into the development of new anticancer therapies targeting membrane molecular complexes consisting of cancer-associated glycolipids and their associated membrane molecules. Thus, a new era of cancer-associated glycosphingolipids has now begun. |
| キーワード |
|
|
主題 |
cancer marker |
| キーワード |
|
|
主題 |
cancer-associated antigen |
| キーワード |
|
|
主題 |
cluster |
| キーワード |
|
|
主題 |
enzyme-mediated activation of radical sources |
| キーワード |
|
|
主題 |
ganglioside |
| キーワード |
|
|
主題 |
glycosphingolipid |
| キーワード |
|
|
主題 |
lipid raft |
| 書誌情報 |
en : Cancer Science
巻 110,
号 5,
p. 1544-1551,
発行日 2019-03-21
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13497006 |
| 出版者 |
|
|
出版者 |
Japanese Cancer Association |
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
| 権利情報 |
|
|
権利情報 |
© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| EID |
|
|
識別子 |
359037 |
| 言語 |
|
|
言語 |
eng |
cas_110_5_1544.pdf (1.2 MB)
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