| Item type |
文献 / Documents(1) |
| 公開日 |
2020-04-16 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.3389/fncel.2013.00012 |
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関連名称 |
10.3389/fncel.2013.00012 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice |
| タイトル別表記 |
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その他のタイトル |
Striatal Cdk5-pTyr15 |
| 著者 |
ヤマムラ, ユキオ
森垣, 龍馬
笠原, 二郎
ヨコヤマ, ヒロノリ
タナベ, アキエ
大北, 真哉
コイズミ, ヒデタカ
永廣, 信治
梶, 龍兒
後藤, 惠
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| 抄録 |
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内容記述 |
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in the striatum. c-Abelson tyrosine kinase (c-Abl) is known to phosphorylate Cdk5 at Tyr15 (Tyr15-Cdk5) and thereby facilitates the Cdk5 activity. We here report that Cdk5 with Tyr15 phosphorylation (Cdk5-pTyr15) is enriched in the mouse striatum, where dopaminergic stimulation inhibited phosphorylation of Tyr15-Cdk5 by acting through the D2 class dopamine receptors. Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. Our results suggest a functional link of Cdk5-pTyr15 with postsynaptic dopamine and glutamate signals through the c-Abl kinase activity in the striatum. |
| キーワード |
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主題 |
cyclin-dependent kinase 5 |
| キーワード |
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|
主題 |
phosphorylation |
| キーワード |
|
|
主題 |
striatum |
| キーワード |
|
|
主題 |
cell signaling |
| 書誌情報 |
en : Frontiers in Cellular Neuroscience
巻 7,
p. 12,
発行日 2013-02-14
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
16625102 |
| 出版者 |
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出版者 |
Frontiers Media S.A. |
| 権利情報 |
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|
権利情報 |
© 2013 Yamamura, Morigaki, Kasahara, Yokoyama, Tanabe, Okita, Koizumi, Nagahiro, Kaji and Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
| EID |
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|
識別子 |
262180 |
| 言語 |
|
|
言語 |
eng |
fncel_7_12.pdf (4.93 MB)
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