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Protective effect of high-affinity liposomes encapsulating astaxanthin against corneal disorder in the in vivo rat dry eye disease model
https://tokushima-u.repo.nii.ac.jp/records/2007663
https://tokushima-u.repo.nii.ac.jp/records/200766365c1b532-ee0a-402e-ae30-3113f741c495
| 名前 / ファイル | ライセンス | アクション |
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jcbn_66_3_224.pdf (739 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
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| 公開日 | 2020-05-28 | |||||||||||||||||||||||
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| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3164/jcbn.19-102 | |||||||||||||||||||||||
| 関連名称 | 10.3164/jcbn.19-102 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Protective effect of high-affinity liposomes encapsulating astaxanthin against corneal disorder in the in vivo rat dry eye disease model | |||||||||||||||||||||||
| 著者 |
シモカワ, タツハル
× シモカワ, タツハル
× 福田, 達也× イナギ, トシウ
× 小暮, 健太朗
WEKO
1139
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| 内容記述 | Oxidative stress induced by decreases in tear volume and excessive tear evaporation is a key factor in dry eye disease (DED). Previously, we reported that desiccation stress induces reactive oxygen species generation and up-regulated expression of age-related markers such as p53, p21 and p16. We also showed that the antioxidant astaxanthin prepared as a liposomal formulation could suppress these phenomena in the in vitro DED model. In this study, we evaluated the protective effect of liposomes encapsulating astaxanthin against superficial punctate keratopathy (SPK) in the in vivo rat DED model. This model of DED was characterized by decreased tear volume and increased fluorescein score as an indicator of SPK as well as upregulated expression of age-related markers. Repeat-dose of liposomal astaxanthin prevented increases in the fluorescein score and up-regulation of age-related markers. Liposomes bearing a slight positive surface charge had superior effects and higher affinity compared to neutral liposomes. Furthermore, fluorescence intensities in rat corneal epithelium after administration of high-affinity liposomes labeled with fluorescent dye were higher than those for neutral liposomes. In conclusion, we developed the high-affinity liposomal formulation that can prevent DED and promote antioxidative effects of astaxanthin. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | dry eye disease | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | oxidative stress | |||||||||||||||||||||||
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| 主題 | age-related markers | |||||||||||||||||||||||
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| 主題 | astaxanthin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | liposomes | |||||||||||||||||||||||
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 巻 66, 号 3, p. 224-232, 発行日 2020-05-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 09120009 | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 18805086 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA10710201 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | Society for Free Radical Research Japan | |||||||||||||||||||||||
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| 権利情報 | © 2020 Society for Free Radical Research Japan | |||||||||||||||||||||||
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| 識別子 | 365848 | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
