WEKO3
アイテム
Protective Effect of Antioxidative Liposomes Co-encapsulating Astaxanthin and Capsaicin on CCl4-Induced Liver Injury
https://tokushima-u.repo.nii.ac.jp/records/2007664
https://tokushima-u.repo.nii.ac.jp/records/20076645f6a8e0a-5baf-463a-8a93-e841c4334056
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bpb_43_8_1272.pdf (352 KB)
|
|
| Item type | 文献 / Documents(1) | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-08-24 | |||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1248/bpb.b20-00116 | |||||||||||||||||||||||
| 関連名称 | 10.1248/bpb.b20-00116 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Protective Effect of Antioxidative Liposomes Co-encapsulating Astaxanthin and Capsaicin on CCl4-Induced Liver Injury | |||||||||||||||||||||||
| 著者 |
福田, 達也
× 福田, 達也× ヒライ, ショウタ
× 吉田, 達貞× マオカ, タカシ
× 小暮, 健太朗
WEKO
1139
|
|||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Our previous study reported that co-encapsulation of potent antioxidants astaxanthin (Asx) and capsaisin (Cap) into liposomes brought about synergistically higher antioxidative activity than the calculated additive activity of each single antioxidant encapsulating liposome. Based on the previous computational chemistry analysis, the synergistic effect was revealed to be resulted from intermolecular interactions between Asx, especially 3R,3′R-form of Asx stereoisomer (Asx-R), and Cap, by which changes of electronic states of the polyene moiety of Asx-R were induced. Although liposomes co-encapsulating Asx-R and Cap (Asx-R/Cap-Lipo) at an optimal ratio clearly showed synergistic antioxidative activity in vitro, it is unclear whether the effective antioxidative activity derived from intermolecular interaction between Asx-R and Cap is also exerted in vivo. Therefore, in this study, we investigated therapeutic potential of Asx-R/Cap-Lipo as an antioxidant formulation in vivo. For this purpose, we employed carbon tetrachloride (CCl4)-induced acute liver injury rat model, since CCl4 is known to cause oxidative damage in liver. CCl4 administration significantly increased the levels of aspartate transaminase (AST) and alanine aminotransferase (ALT). Intravenous combined administration of liposomes encapsulating Asx-R (Asx-R-Lipo) and liposomes encapsulating Cap (Cap-Lipo) significantly decreased CCl4-induced increase of AST and ALT levels. Importantly, the treatment with Asx-R/Cap-Lipo tended to show higher protective effect on acute liver injury than combined treatment with Asx-R-Lipo plus Cap-Lipo. These results suggest that co-encapsulated Asx-R and Cap in liposomal membranes could exert more effective antioxidative activities in vivo, and that Asx-R/Cap-Lipo would be a hopeful antioxidant formulation for treating reactive oxygen species-related diseases. | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | antioxidant | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | astaxanthin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | capsaicin | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | liposome | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | intermolecular interaction | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | stereochemistry | |||||||||||||||||||||||
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 43, 号 8, p. 1272-1274, 発行日 2020-08-01 |
|||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 09186158 | |||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 13475215 | |||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA10885497 | |||||||||||||||||||||||
| 収録物ID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11696048 | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||||||||||||||||||
| EID | ||||||||||||||||||||||||
| 識別子 | 365842 | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
