| Item type |
文献 / Documents(1) |
| 公開日 |
2020-06-15 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1242/bio.201411064 |
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関連名称 |
10.1242/bio.201411064 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Short germ insects utilize both the ancestral and derived mode of Polycomb group-mediated epigenetic silencing of Hox genes |
| 著者 |
マツオカ, ユウジ
バンドウ, テツヤ
渡辺, 崇人
石丸, 善康
野地, 澄晴
Popadić, Aleksandar
三戸, 太郎
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| 抄録 |
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内容記述 |
In insect species that undergo long germ segmentation, such as Drosophila, all segments are specified simultaneously at the early blastoderm stage. As embryogenesis progresses, the expression boundaries of Hox genes are established by repression of gap genes, which is subsequently replaced by Polycomb group (PcG) silencing. At present, however, it is not known whether patterning occurs this way in a more ancestral (short germ) mode of embryogenesis, where segments are added gradually during posterior elongation. In this study, two members of the PcG family, Enhancer of zeste (E(z)) and Suppressor of zeste 12 (Su(z)12), were analyzed in the short germ cricket, Gryllus bimaculatus. Results suggest that although stepwise negative regulation by gap and PcG genes is present in anterior members of the Hox cluster, it does not account for regulation of two posterior Hox genes, abdominal-A (abd-A) and Abdominal-B (Abd-B). Instead, abd-A and Abd-B are predominantly regulated by PcG genes, which is the mode present in vertebrates. These findings suggest that an intriguing transition of the PcG-mediated silencing of Hox genes may have occurred during animal evolution. The ancestral bilaterian state may have resembled the current vertebrate mode of regulation, where PcG-mediated silencing of Hox genes occurs before their expression is initiated and is responsible for the establishment of individual expression domains. Then, during insect evolution, the repression by transcription factors may have been acquired in anterior Hox genes of short germ insects, while PcG silencing was maintained in posterior Hox genes. |
| キーワード |
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主題 |
Epigenetic silencing |
| キーワード |
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主題 |
Gene expression |
| キーワード |
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主題 |
Hox genes |
| キーワード |
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主題 |
Insect |
| キーワード |
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|
主題 |
Polycomb group genes |
| 書誌情報 |
en : Biology Open
巻 4,
号 6,
p. 702-709,
発行日 2015-06-15
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20466390 |
| 出版者 |
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出版者 |
The Company of Biologists |
| 権利情報 |
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|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| EID |
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|
識別子 |
292652 |
| 言語 |
|
|
言語 |
eng |
bio_4_6_702.pdf (769 KB)
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