| Item type |
文献 / Documents(1) |
| 公開日 |
2020-05-28 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/elps.202000066 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1002/elps.202000066 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
|
|
タイトル |
Determination of acid dissociation constants of flavin analogues by capillary zone electrophoresis |
|
言語 |
en |
| 著者 |
タニカミ, ユウキ
タガミ, タクマ
サカモト, マユ
荒川, 幸弘
水口, 仁志
今田, 泰嗣
髙栁, 俊夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Acid dissociation constants (pKa) of 9 kinds of flavin analogues as molecular catalyst candidates were determined by CZE. Although some of the analogues are instable and degradable under the light-exposure or in alkaline aqueous solutions, the effective electrophoretic mobility of the flavin analogue of interest has been measured with the residual substance. The pKa values of the flavin analogues were analyzed through the changes in the effective electrophoretic mobility with varying pH of the separation buffer. One or two steps pKa values were determined by the analysis. One of the degraded species from the flavin analogues, lumichrome, was also detected in the CZE analysis, and its pKa values were also determined. While coexisting impurities generated over the storage conditions were found in some analogues, the pKa values of the target analogues were successfully determined with the help of the CZE separations. A pressure-assisted CZE was utilized for the determination or the estimation of the pKa values of such analogues as possessing carboxylic acid moiety. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Acid dissociation constant |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Flavin analogues |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Instable substances |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Capillary zone electrophoresis |
| 書誌情報 |
en : Electrophoresis
巻 41,
号 15,
p. 1316-1325,
発行日 2020-05-09
|
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
15222683 |
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
01730835 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00179882 |
| 出版者 |
|
|
出版者 |
WILEY-VCH |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is the peer reviewed version of the following article: Tanikami, Y., Tagami, T., Sakamoto, M., Arakawa, Y., Mizuguchi, H., Imada, Y. and Takayanagi, T. (2020), Determination of acid dissociation constants of flavin analogues by capillary zone electrophoresis. ELECTROPHORESIS, 41: 1316-1325., which has been published in final form at https://doi.org/10.1002/elps.202000066. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| EID |
|
|
識別子 |
365574 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
elps_41_15_1316.pdf (423 KB)
