| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-25 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s41467-018-03845-1 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1038/s41467-018-03845-1 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration |
|
言語 |
en |
| 著者 |
ハラダ, アキヒト
マエハラ, カズミツ
オノ, ユウスケ
タグチ, ヒロユキ
ヨシオカ, キヨシ
キタジマ, ヤスオ
Xie, Yan
サトウ, ユウコ
イワサキ, タケシ
ノガミ, ジュンペイ
オカダ, セイジ
コマツ, テツロウ
センバ, ユウイチロウ
竹本, 龍也
キムラ, ヒロシ
クルミザカ, ヒトシ
オオカワ, ヤスユキ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Regulation of gene expression requires selective incorporation of histone H3 variant H3.3 into chromatin. Histone H3.3 has several subsidiary variants but their functions are unclear. Here we characterize the function of histone H3.3 sub-variant, H3mm7, which is expressed in skeletal muscle satellite cells. H3mm7 knockout mice demonstrate an essential role of H3mm7 in skeletal muscle regeneration. Chromatin analysis reveals that H3mm7 facilitates transcription by forming an open chromatin structure around promoter regions including those of myogenic genes. The crystal structure of the nucleosome containing H3mm7 reveals that, unlike the S57 residue of other H3 proteins, the H3mm7-specific A57 residue cannot form a hydrogen bond with the R40 residue of the cognate H4 molecule. Consequently, the H3mm7 nucleosome is unstable in vitro and exhibited higher mobility in vivo compared with the H3.3 nucleosome. We conclude that the unstable H3mm7 nucleosome may be required for proper skeletal muscle differentiation. |
|
言語 |
en |
| 書誌情報 |
en : Nature Communications
巻 9,
p. 1400,
発行日 2018-04-11
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20411723 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12645905 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2018 |
| EID |
|
|
識別子 |
353193 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
ncomms_9_1400.pdf (3.11 MB)
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