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Effect of Semaphorin7A during the Effector Phase of Nickel Allergy
https://tokushima-u.repo.nii.ac.jp/records/2007772
https://tokushima-u.repo.nii.ac.jp/records/2007772ca848179-e587-4335-8911-fcfe3b6a012f
| 名前 / ファイル | ライセンス | アクション |
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johb_33_1_8.pdf (1.79 MB)
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k3427_abstract.pdf (164 KB)
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k3427_review.pdf (48.9 KB)
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k3427_fulltext.pdf (495 KB)
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| Item type | 文献 / Documents(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-06-05 | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 出版社版DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.20738/johb.33.1_8 | |||||||||
| 言語 | ja | |||||||||
| 関連名称 | 10.20738/johb.33.1_8 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| タイトル | ||||||||||
| タイトル | Effect of Semaphorin7A during the Effector Phase of Nickel Allergy | |||||||||
| 言語 | en | |||||||||
| タイトル別表記 | ||||||||||
| その他のタイトル | ニッケルアレルギー惹起相におけるセマフォリン７Aの効果 | |||||||||
| 言語 | ja | |||||||||
| 著者 |
南, 憲一
× 南, 憲一× 渡邉, 恵× Liu, Lipei
× Yunizar, Mohammad Fadyl
× 市川, 哲雄 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Background: Metal allergy is caused by many factors, including cells, cytokines, chemokines, or the environment. Recent studies suggested semaphorin7A (Sema7A), expressed on activated T cells, is crucial to produce inflammation through α1β1 integrin on monocytes and macrophages. However, the role of Sema7A on keratinocytes in metal allergy is still unclear. In this study, we focused on keratinocytes since they are known as an important player for skin immunity, and analyzed the effect of Sema7A expressed on keratinocytes in the development of metal allergy. Materials and Methods: Mouse keratinocyte line PAM2.12 cells were treated with NiCl2 to analyze the expression of Sema7A. Ni allergy was induced in female C57BL/6J mice (6-8 weeks old) with or without Sema7A suppression to confirm if Sema7A is necessary to produce allergic reactions to NiCl2. Results: NiCl2 enhanced the expression of Sema7A in a dose and time-dependent manner after 72 hours of stimulation. PAM 2.12 produced TNF-α in response to NiCl2, and this secretion was reduced by Sema7A inhibition. In a mouse model, ear thickness, at 48 hours after NiCl2 injection, was significantly decreased by Sema7A siRNA administration. Conclusions: Sema7A is essential to produce an allergic reaction to NiCl2, especially during the effector phase. Since the interaction between Sema7A and α1β1 integrin enhances inflammation in many skin diseases, this interaction may also have possibilities to be a therapeutic target for metal allergy. |
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| 言語 | en | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Nickel Allergy | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Semaphorin7A | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Keratinocyte | |||||||||
| 書誌情報 |
en : Journal of Oral Health and Biosciences 巻 33, 号 1, p. 8-14, 発行日 2020-06-12 |
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| 収録物ID | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 21896682 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Shikoku Society of Dental Research | |||||||||
| 言語 | en | |||||||||
| 備考 | ||||||||||
| 言語 | ja | |||||||||
| 値 | 内容要旨・審査要旨・論文本文の公開 本論文は，著者Norikazu MINAMIの学位論文として提出され，学位審査・授与の対象となっている。 学位授与者所属 : 徳島大学大学院口腔科学教育部（口腔科学専攻） |
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| EID | ||||||||||
| 識別子 | 367739 | |||||||||
| 識別子タイプ | URI | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 報告番号 | ||||||||||
| 学位授与番号 | 甲第3427号 | |||||||||
| 学位記番号 | ||||||||||
| 言語 | ja | |||||||||
| 値 | 甲口第463号 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2020-05-14 | |||||||||
| 学位名 | ||||||||||
| 言語 | ja | |||||||||
| 学位名 | 博士（歯学） | |||||||||
| 学位授与機関 | ||||||||||
| 言語 | ja | |||||||||
| 学位授与機関名 | 徳島大学 | |||||||||
