Item type |
文献 / Documents(1) |
公開日 |
2020-07-13 |
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アクセス権 |
open access |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版社版DOI |
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関連識別子 |
https://doi.org/10.1111/cas.14234 |
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関連名称 |
10.1111/cas.14234 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
タイトル |
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タイトル |
Significant association between high serum CCL5 levels and better disease‐free survival of patients with early breast cancer |
著者 |
フジモト, ユキエ
イノウエ, ナツコ
モリモト, コウジ
ワタナベ, タカヒロ
ヒロタ, セイイチ
イマムラ, ミチコ
松下, 洋輔
片桐, 豊雅
オカムラ, ハルキ
ミヨシ, ヤスオ
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抄録 |
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内容記述 |
Analysis of anticancer immunity aids in assessing the prognosis of patients with breast cancer. From 250 operated breast cancers, we focused on serum levels of C-C motif chemokine ligand 5 (CCL5), which is involved in cancer immune reactions. Serum levels of CCL5 were measured using a cytometric bead-based immunoassay kit and CCL5 expression in cancer cells was determined using immunohistochemical staining. In addition, mRNA in cancer and stromal cells was analyzed by microdissection and comparison with the public dataset. Disease-free survival (DFS) of patients with high CCL5 levels (cut-off, 13.87 ng/mL; n = 192) was significantly better than those with low CCL5 levels (n = 58; hazard ratio, 0.20; 95% confidence interval, 0.10- 0.39; P < .0001). An improved overall survival was observed in patients with high CCL5 levels compared to those with low CCL5 levels (P = .024). On the contrary, high immunohistochemical expression of CCL5 in cancer cells was significantly associated with decreased DFS. As serum CCL5 levels did not correlate with CCL5 expression in cancer cells and the relative expression of mRNA CCL5 was elevated in stromal cells in relation to cancer cells, serum CCL5 might be derived not from cancer cells, but from stromal cells. Expression of CCL5 in serum, but not in cancer cells, might contribute to improved patient prognosis mediating through not only immune reaction, but through other mechanisms. Determination of circulating CCL5 levels could be useful for predicting patient prognosis. |
キーワード |
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主題 |
breast cancer |
キーワード |
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主題 |
CCL5 |
キーワード |
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主題 |
cytokine |
キーワード |
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主題 |
immunity |
キーワード |
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主題 |
prognosis |
書誌情報 |
en : Cancer Science
巻 111,
号 1,
p. 209-218,
発行日 2019-11-14
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収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13497006 |
出版者 |
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出版者 |
Japanese Cancer Association |
出版者 |
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出版者 |
John Wiley & Sons |
権利情報 |
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権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
EID |
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識別子 |
364851 |
言語 |
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言語 |
eng |