| Item type |
文献 / Documents(1) |
| 公開日 |
2020-07-17 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3389/fpsyt.2019.00312 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3389/fpsyt.2019.00312 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
mtDNA and Hemodynamics in Mood Disorders |
|
言語 |
en |
| 著者 |
ツジイ, ノア
オオツカ, イクオ
オカザキ, サトシ
ヤナギ, マサヤ
沼田, 周助
ヤマキ, ナルヒサ
カワクボ, ヨシヒロ
シラカワ, オサム
ヒシモト, アキトヨ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Given a lack of markers, diagnoses of bipolar disorder (BD) and major depressive disorder (MDD) rely on clinical assessment of symptoms. However, the depressive mood states of BD and depressive symptoms of MDD are often difficult to distinguish, which leads to misdiagnoses, which in turn leads to inadequate treatment. Previous studies have shown that the hemodynamic responses of the left frontopolar cortex measured by near-infrared spectroscopy (NIRS) differ between BD and MDD; these hemodynamic responses are associated with altered mitochondrial metabolism; and mitochondrial DNA copy number (mtDNAcn), an index of mitochondrial dysfunction, tends to decrease in BD and increase in MDD patients. In this study, we confirmed that mtDNAcn trends in opposite directions in BD and MDD. We then determined whether mtDNAcn could enhance the utility of NIRS as a diagnostic marker to distinguish between BD and MDD.
Methods: We determined mtDNAcn in peripheral blood samples from 58 healthy controls, 79 patients with BD, and 44 patients with MDD. Regional hemodynamic responses during a verbal fluency task (VFT) in 24 BD patients and 44 MDD patients, matched by age and depression severity, were monitored using NIRS.
Results: Measurements of mtDNAcn were lower in BD patients and higher in MDD patients than in controls. The left frontopolar region exhibited the most significant differences in mean VFT-related oxy-Hb changes between the BD and MDD groups. Multivariate logistic regression analysis with variables including age, sex, hemodynamic response of the left frontopolar region, and mtDNAcn showed high accuracy for distinguishing BD from MDD (area under the curve = 0.917; 95% confidence interval = 0.849–0.985). For the BD group, we observed a positive correlation between hemodynamic responses in the left frontopolar region and mtDNAcn, while for the MDD group, we observed a negative correlation.
Conclusions: Our findings suggest that the association between hemodynamic response and mitochondrial dysfunction in BD or MDD plays an important role in differentiating the pathophysiological mechanisms of BD from those of MDD. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bipolar disorder |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
major depressive disorder |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hemodynamics |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mitochondria |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
near-infrared spectroscopy |
| 書誌情報 |
en : Frontiers in Psychiatry
巻 10,
p. 312,
発行日 2019-05-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16640640 |
| 出版者 |
|
|
出版者 |
Frontiers Media S.A. |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2019 Tsujii, Otsuka, Okazaki, Yanagi, Numata, Yamaki, Kawakubo, Shirakawa and Hishimoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| EID |
|
|
識別子 |
365491 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
fpsyt_10_312.pdf (2.67 MB)
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