| Item type |
文献 / Documents(1) |
| 公開日 |
2020-07-22 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.1371/journal.pone.0139692 |
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関連名称 |
10.1371/journal.pone.0139692 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo |
| タイトル別表記 |
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その他のタイトル |
CD98 and T Cell Activation |
| 著者 |
クリハラ, タケシ
有持, 秀喜
Bhuyan, Zaied Ahmed
石舟, 智恵子
ツムラ, ヒデキ
イトウ, モリヒロ
イトウ, ヤスヒコ
北村, 明子
前川, 洋一
安友, 康二
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| 抄録 |
|
|
内容記述 |
Upon their recognition of antigens presented by the MHC, T cell proliferation is vital for clonal expansion and the acquisition of effector functions, which are essential for mounting adaptive immune responses. The CD98 heavy chain (CD98hc, Slc3a2) plays a crucial role in the proliferation of both CD4+ and CD8+ T cells, although it is unclear if CD98hc directly regulates the T cell effector functions that are not linked with T cell proliferation in vivo. Here, we demonstrate that CD98hc is required for both CD4+ T cell proliferation and Th1 functional differentiation. T cell-specific deletion of CD98hc did not affect T cell development in the thymus. CD98hc-deficient CD4+ T cells proliferated in vivo more slowly as compared with control T cells. C57BL/6 mice lacking CD98hc in their CD4+ T cells could not control Leishmania major infections due to lowered IFN-γ production, even with massive CD4+ T cell proliferation. CD98hc-deficient CD4+ T cells exhibited lower IFN-γ production compared with wild-type T cells, even when comparing IFN-γ expression in cells that underwent the same number of cell divisions. Therefore, these data indicate that CD98hc is required for CD4+ T cell expansion and functional Th1 differentiation in vivo, and suggest that CD98hc might be a good target for treating Th1-mediated immune disorders. |
| 書誌情報 |
en : PLOS ONE
巻 10,
号 10,
p. e0139692,
発行日 2015-10-07
|
| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19326203 |
| 出版者 |
|
|
出版者 |
PLOS |
| 権利情報 |
|
|
権利情報 |
© 2015 Kurihara et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
|
|
識別子 |
311277 |
| 言語 |
|
|
言語 |
eng |
pone_10_10_e0139692.pdf (1.63 MB)
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