| Item type |
文献 / Documents(1) |
| 公開日 |
2020-07-22 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0136835 |
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関連名称 |
10.1371/journal.pone.0136835 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer’s Disease and Schizophrenia |
| タイトル別表記 |
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その他のタイトル |
TREM2 Expression in Schizophrenia |
| 著者 |
モリ, ヨウコ
ヨシノ, ユウタ
オチ, シンイチロウ
ヤマザキ, キヨヒロ
カワベ, ケンタロウ
アベ, マサオ
キタノ, トモジ
オザキ, ユウキ
ヨシダ, タク
沼田, 周助
モリ, タカアキ
伊賀, 淳一
クロダ, ノリオ
大森, 哲郎
上野, 修一
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| 抄録 |
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内容記述 |
TREM2 and TYROBP are causal genes for Nasu–Hakola disease (NHD), a rare autosomal recessive disease characterized by bone lesions and early-onset progressive dementia. TREM2 forms a receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages and dendritic cells, and the functional polymorphism of TREM2 is reported to be associated with neurodegenerative disorders such as Alzheimer’s disease (AD). The objective of this study was to reveal the involvement of TYROBP and TREM2 in the pathophysiology of AD and schizophrenia. Methods: We investigated the mRNA expression level of the 2 genes in leukocytes of 26 patients with AD and 24 with schizophrenia in comparison with age-matched controls. Moreover, we performed gene association analysis between these 2 genes and schizophrenia. Results: No differences were found in TYROBP mRNA expression in patients with AD and schizophrenia; however, TREM2 mRNA expression was increased in patients with AD and schizophrenia compared with controls (P < 0.001). There were no genetic associations of either gene with schizophrenia in Japanese patients. Conclusion: TREM2 expression in leukocytes is elevated not only in AD but also in schizophrenia. Inflammatory processes involving TREM2 may occur in schizophrenia, as observed in neurocognitive disorders such as AD. TREM2 expression in leukocytes may be a novel biomarker for neurological and psychiatric disorders. |
| 書誌情報 |
en : PLOS ONE
巻 10,
号 9,
p. e0136835,
発行日 2015-09-02
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
19326203 |
| 出版者 |
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出版者 |
PLOS |
| 権利情報 |
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権利情報 |
© 2015 Mori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| EID |
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識別子 |
304097 |
| 言語 |
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言語 |
eng |
pone_10_9_e0136835.pdf (765 KB)
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