| Item type |
文献 / Documents(1) |
| 公開日 |
2020-08-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1038/srep15888 |
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関連名称 |
10.1038/srep15888 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men |
| 著者 |
コヤマ, テルヒデ
マツイ, ダイスケ
クリヤマ, ナガト
オザキ, エツコ
タナカ, ケイタロウ
オゼ, イサオ
ハマジマ, ノブユキ
ワカイ, ケンジ
オカダ, リエコ
有澤, 孝吉
ミカミ, ハルオ
シマタニ, ケイイチ
ヒラタ, アキエ
タカシマ, ナオユキ
スズキ, サダオ
ナガタ, チサト
クボ, ミチアキ
タナカ, ヒデオ
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| 抄録 |
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内容記述 |
Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Therefore, we examined SLC17A1 polymorphisms (rs1165196, rs1179086 and rs3757131), which might suppress cardiovascular risk factors and that are involved in liver functioning, via a large-scale pooled analysis of the Japanese general population in a cross-sectional study. Using data from the Japan Multi-Institutional Collaborative Cohort Study, we identified 1842 participants of both sexes, 35–69-years-old, having the requisite data and analysed their SLC17A1 genotypes. In men, logistic regression analyses revealed that minor alleles in SLC17A1 polymorphisms (rs1165196 and rs3757131) were associated with a low-/high-density lipoprotein cholesterol ratio >2.0 (rs1165196: odds ratio [OR], 0.703; 95% confidence interval [CI], 0.536–0.922; rs3757131: OR, 0.658; 95% CI, 0.500–0.866) and with homocysteine levels of >10.0 nmol/mL (rs1165196: OR, 0.544; 95% CI, 0.374–0.792; rs3757131: OR, 0.509; 95% CI, 0.347–0.746). Therefore, these polymorphisms had dominant negative effects on cholesterol homeostasis and hyperhomocysteinaemia, in men, independent of alcohol consumption, physical activity, or daily energy and nutrition intake. Thus, genetic variants of SLC17A1 are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men. |
| 書誌情報 |
en : Scientific Reports
巻 5,
p. 15888,
発行日 2015-11-03
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
| 出版者 |
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出版者 |
Springer Nature |
| 権利情報 |
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権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
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識別子 |
305285 |
| 言語 |
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言語 |
eng |
srep_5_15888.pdf (478 KB)
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