| Item type |
文献 / Documents(1) |
| 公開日 |
2020-08-06 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/srep15885 |
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言語 |
ja |
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関連名称 |
10.1038/srep15885 |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Knockout crickets for the study of learning and memory : Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets |
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言語 |
en |
| 著者 |
アワタ, ヒロコ
渡辺, 崇人
ハマナカ, ヨシタカ
三戸, 太郎
野地, 澄晴
ミズナミ, マコト
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Elucidation of reinforcement mechanisms in associative learning is an important subject in neuroscience. In mammals, dopamine neurons are thought to play critical roles in mediating both appetitive and aversive reinforcement. Our pharmacological studies suggested that octopamine and dopamine neurons mediate reward and punishment, respectively, in crickets, but recent studies in fruit-flies concluded that dopamine neurons mediates both reward and punishment, via the type 1 dopamine receptor Dop1. To resolve the discrepancy between studies in different insect species, we produced Dop1 knockout crickets using the CRISPR/Cas9 system and found that they are defective in aversive learning with sodium chloride punishment but not appetitive learning with water or sucrose reward. The results suggest that dopamine and octopamine neurons mediate aversive and appetitive reinforcement, respectively, in crickets. We suggest unexpected diversity in neurotransmitters mediating appetitive reinforcement between crickets and fruit-flies, although the neurotransmitter mediating aversive reinforcement is conserved. This study demonstrates usefulness of the CRISPR/Cas9 system for producing knockout animals for the study of learning and memory. |
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言語 |
en |
| 書誌情報 |
en : Scientific Reports
巻 5,
p. 15885,
発行日 2015-11-02
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
| 出版者 |
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出版者 |
Springer Nature |
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言語 |
en |
| 権利情報 |
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言語 |
en |
|
権利情報 |
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EID |
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識別子 |
307537 |
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識別子タイプ |
URI |
| 言語 |
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言語 |
eng |
srep_5_15885.pdf (1.09 MB)
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