| Item type |
文献 / Documents(1) |
| 公開日 |
2020-09-18 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/brb3.510 |
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言語 |
ja |
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|
関連名称 |
10.1002/brb3.510 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
CBT reduces CBF : cognitive‐behavioral therapy reduces cerebral blood flow in fear‐relevant brain regions in spider phobia |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
CBT Reduces CBF |
|
言語 |
en |
| 著者 |
Soravia, Leila M.
Orosz, Ariane
Schwab, Simon
中瀧, 理仁
Wiest, Roland
Federspiel, Andrea
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Imaging studies have provided evidence that cognitive‐behavioral therapy (CBT ) is able to change brain activation in phobic patients in response to threatening stimuli. The changes occurred in both emotion‐generating and modulatory regions. In this study, we use a data‐driven approach to explore resting state cerebral blood flow (CBF ) measured by arterial spin labeling (ASL ), before and after CBT. Methods: Eight female patients with spider phobia were scanned before and 1 month after an exposure‐based group therapy for spider phobia. Each MRI session consisted of an ASL resting state measurement acquired before and after a symptom provocation task involving the showing of spider pictures in the scanner. The first ASL acquisition measured anticipatory anxiety and the second measured postprocessing of phobia‐relevant stimuli. Results: Cognitive‐behavioral therapy significantly reduced spider phobic symptoms in all patients. Symptom reduction during anticipatory anxiety was accompanied by reduced bilateral CBF in the parahippocampal gyrus, ventral anterior thalamus, Brodmann area 8, and the anterior cingulate cortex. During postprocessing of phobia‐relevant stimuli, patients showed reduced CBF in the bilateral insula, components of the motor cortex, and areas associated with language functions. Conclusions: Longitudinal CBF dynamics following CBT were in concordance with results from several studies using BOLD fMRI to investigate the effects of psychotherapy on brain activity. CBF can be quantified by ASL , with the principal advantage of sensitivity to slow variations in neural activity and task independence. Therefore, ASL may be a suitable method for monitoring and evaluating the efficacy of psychotherapy or pharmacotherapy approaches. |
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言語 |
en |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anticipatory anxiety |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
arterial spin labeling |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cerebral blood flow |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cognitive-behavioral therapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fear processing |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phobia |
| 書誌情報 |
en : Brain and Behavior
巻 6,
号 9,
p. e00510,
発行日 2016-07-06
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21623279 |
| 出版者 |
|
|
出版者 |
Wiley Periodicals |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
328970 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
brb_6_9_e00510.pdf (359 KB)
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