| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-30 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/psp4.12292 |
|
|
言語 |
ja |
|
|
関連名称 |
10.1002/psp4.12292 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals : The Potential Impact of the Disulfide Bond‐Forming Oxidoreductase A‐Like Protein (DsbA‐L) Polymorphism on the Weight Status |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
Prediction Models for BMI and NAFLD |
|
言語 |
en |
| 著者 |
オニキ, ケンタロウ
ワタナベ, タケヒサ
クドウ, ミク
イヅカ, トモコ
オノ, タツマサ
マツダ, カズキ
サカモト, ユウキ
ナガオカ, カツヤ
イマフク, タダシ
異島, 優
ワタナベ, ヒロシ
マルヤマ, トオル
オオタケ, コウジ
オガタ, ヤスヒロ
サルワタリ, ジュンジ
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity. Disulfide bond‐forming oxidoreductase A‐like protein (DsbA‐L) is known to be a key molecule in protection against obesity and obesity‐induced inflammation. In the present study, we used a modeling and simulation approach in an attempt to develop body mass index (BMI) and BMI‐based NAFLD prediction models incorporating the DsbA‐L polymorphism to predict the BMI and NAFLD in 341 elderly subjects. A nonlinear mixed‐effect model best represented the sigmoidal relationship between the BMI and the logit function of the probability of NAFLD prevalence. The final models for BMI and NAFLD showed that DsbA‐L rs1917760 polymorphism, age, and gender were associated with the BMI, whereas gender, patatin‐like phospholipase 3 rs738409 polymorphism, HbA1c, and high‐density and low‐density lipoprotein cholesterol levels were associated with the risk of NAFLD. This information may aid in the genetic‐based prevention of obesity and NAFLD in the general elderly population. |
|
言語 |
en |
| 書誌情報 |
en : CPT: Pharmacometrics & Systems Pharmacology
巻 7,
号 6,
p. 384-393,
発行日 2018-03-23
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| 収録物ID |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
21638306 |
| 出版者 |
|
|
出版者 |
American Society for Clinical Pharmacology and Therapeutics |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| EID |
|
|
識別子 |
356613 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
psp_7_6_384.pdf (504 KB)
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