| Item type |
文献 / Documents(1) |
| 公開日 |
2020-12-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.7554/eLife.38883 |
|
|
関連名称 |
10.7554/eLife.38883 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Hair follicle epidermal stem cells define a niche for tactile sensation |
| 著者 |
Cheng, Chun-Chun
ツツイ, コウ
タグチ, トオル
サンゼン, ノリコ
ナカガワ, アサコ
カキグチ, キサ
米村, 重信
タネガシマ, チハル
Keeley, Sean D
キヨナリ, ヒロシ
フルタ, ヤスヒデ
トモノ, ヤスコ
Watt, Fiona M
フジワラ, ヒロノブ
|
| 抄録 |
|
|
内容記述 |
The heterogeneity and compartmentalization of stem cells is a common principle in many epithelia, and is known to function in epithelial maintenance, but its other physiological roles remain elusive. Here we show transcriptional and anatomical contributions of compartmentalized epidermal stem cells in tactile sensory unit formation in the mouse hair follicle. Epidermal stem cells in the follicle upper-bulge, where mechanosensory lanceolate complexes innervate, express a unique set of extracellular matrix (ECM) and neurogenesis-related genes. These epidermal stem cells deposit an ECM protein called EGFL6 into the collar matrix, a novel ECM that tightly ensheathes lanceolate complexes. EGFL6 is required for the proper patterning, touch responses, and αv integrin-enrichment of lanceolate complexes. By maintaining a quiescent original epidermal stem cell niche, the old bulge, epidermal stem cells provide anatomically stable follicle–lanceolate complex interfaces, irrespective of the stage of follicle regeneration cycle. Thus, compartmentalized epidermal stem cells provide a niche linking the hair follicle and the nervous system throughout the hair cycle. |
| 書誌情報 |
en : eLife
巻 7,
p. e38883,
発行日 2018-10-25
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2050084X |
| 出版者 |
|
|
出版者 |
eLife Sciences Publications |
| 権利情報 |
|
|
権利情報 |
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| EID |
|
|
識別子 |
355306 |
| 言語 |
|
|
言語 |
eng |
elife_7_e38883.pdf (8.35 MB)
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