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Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

https://tokushima-u.repo.nii.ac.jp/records/2008163
https://tokushima-u.repo.nii.ac.jp/records/2008163
c94b2a49-8265-49de-8a73-f5d04380187f
名前 / ファイル ライセンス アクション
ncomms_10_5498.pdf ncomms_10_5498.pdf (3.45 MB)
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Item type 文献 / Documents(1)
公開日 2020-12-25
アクセス権
アクセス権 open access
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版社版DOI
関連識別子 https://doi.org/10.1038/s41467-019-13465-y
関連名称 10.1038/s41467-019-13465-y
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
タイトル
タイトル Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
著者 Cowan, Jennifer E.

× Cowan, Jennifer E.

en Cowan, Jennifer E.

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Malin, Justin

× Malin, Justin

en Malin, Justin

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Zhao, Yongge

× Zhao, Yongge

en Zhao, Yongge

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Seedhom, Mina O.

× Seedhom, Mina O.

en Seedhom, Mina O.

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Harly, Christelle

× Harly, Christelle

en Harly, Christelle

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大東, いずみ

× 大東, いずみ

WEKO 424
徳島大学 教育研究者総覧 207340/profile-ja.html
e-Rad 00596588

ja 大東, いずみ
ISNI

ja-Kana オオヒガシ, イズミ

en Ohigashi, Izumi

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Kelly, Michael

× Kelly, Michael

en Kelly, Michael

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高浜, 洋介

× 高浜, 洋介

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徳島大学 教育研究者総覧 60028/profile-ja.html
e-Rad 20183858

ja 高浜, 洋介
ISNI

ja-Kana タカハマ, ヨウスケ

en Takahama, Yousuke

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Yewdell, Jonathan W.

× Yewdell, Jonathan W.

en Yewdell, Jonathan W.

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Cam, Maggie

× Cam, Maggie

en Cam, Maggie

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Bhandoola, Avinash

× Bhandoola, Avinash

en Bhandoola, Avinash

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抄録
内容記述 Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, including proliferation rates, engraftability and function. Further analyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thymus size during fetal life. Enforced Myc expression in TEC induces the prolonged maintenance of a fetal-specific transcriptional program, which in turn extends the growth phase of the thymus and enhances thymic output; meanwhile, inducible expression of Myc in adult TEC similarly promotes thymic growth. Mechanistically, this Myc function is associated with enhanced ribosomal biogenesis in TEC. Our study thus identifies age-specific transcriptional programs in TEC, and establishes that Myc controls thymus size.
書誌情報 en : Nature Communications

巻 10, p. 5498, 発行日 2019-12-02
収録物ID
収録物識別子タイプ ISSN
収録物識別子 20411723
収録物ID
収録物識別子タイプ NCID
収録物識別子 AA12645905
出版者
出版者 Springer Nature
権利情報
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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識別子 362361
言語
言語 eng
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