| Item type |
文献 / Documents(1) |
| 公開日 |
2021-01-08 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1248/bpb.b20-00573 |
|
|
関連名称 |
10.1248/bpb.b20-00573 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Suppression of Lipid Accumulation in 3T3-L1 Adipocytes by α-Tocopheryl Succinate |
| 著者 |
マジマ, ダイ
ミツハシ, リョウスケ
ヤマサキ, ミサキ
カジモト, カズアキ
福田, 達也
小暮, 健太朗
|
| 抄録 |
|
|
内容記述 |
Obesity is a pathological state related to various lifestyle-related diseases, such as diabetes and dyslipidemia, that may be prevented through the development of anti-obesity treatments. Lipid accumulation in cells could be affected by vitamin E ester α-tocopheryl succinate (TS), which has various biological activities, such as anti-cancer effect, via activation of cell signaling pathways, although the antioxidative activity of TS is lost due to esterification of the phenolic OH group. In this study, we found for the first time that TS significantly suppressed lipid accumulation in mouse 3T3-L1 adipocytes. TS treatment reduced the amount of triglycerides in the culture medium, and inhibited activity of glycerol-3-phosphate dehydrogenase, a marker of lipid synthesis. Furthermore, TS accelerated lipolysis. Treatment of adipocytes with TS for 24 h induced no significant cytotoxicity. In TS-treated cells, phosphorylation of Akt, which is involved in fatty acid synthesis via sterol regulatory element-binding proteins (SREBP), was prevented, while levels of phosphorylated protein kinase A (PKA) did not change. Taken together, these results suggest that vitamin E ester TS can suppress lipid accumulation in adipocytes by regulating lipid metabolic cell signaling. |
| キーワード |
|
|
主題 |
tocopheryl succinate |
| キーワード |
|
|
主題 |
adipocyte |
| キーワード |
|
|
主題 |
lipolysis |
| キーワード |
|
|
主題 |
anti-obesity |
| 書誌情報 |
en : Biological and Pharmaceutical Bulletin
巻 44,
号 1,
p. 46-50,
発行日 2021-01-01
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09186158 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13475215 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10885497 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11696048 |
| 出版者 |
|
|
出版者 |
The Pharmaceutical Society of Japan |
| EID |
|
|
識別子 |
371853 |
| 言語 |
|
|
言語 |
eng |
bpb_44_1_46.pdf (1.06 MB)
