| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-01 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.1016/j.kint.2020.10.041 |
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|
関連名称 |
10.1016/j.kint.2020.10.041 |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity |
| タイトル別表記 |
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その他のタイトル |
Efficacy of diphenhydramine as a preventive medicine against cisplatin-induced nephrotoxicity |
| タイトル別表記 |
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|
その他のタイトル |
Diphenhydramine against cisplatin nephrotoxicity |
| 著者 |
濱野, 裕章
池田, 康将
合田, 光寛
福島, 圭穣
岸, 誠司
中馬, 真幸
山下, 理子
新村, 貴博
武智, 研志
今西, 正樹
座間味, 義人
堀ノ内, 裕也
(井澤)石澤, 有紀
宮本, 理人
石澤, 啓介
藤野, 裕道
玉置, 俊晃
粟飯原, 賢一
土屋, 浩一郎
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| 抄録 |
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内容記述 |
Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes nephrotoxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced nephrotoxicity is currently available. This study identified that a previously developed drug, diphenhydramine, may provide a novel treatment for cisplatin-induced nephrotoxicity based on the results of the analysis of medical big data. We evaluated the actual efficacy of diphenhydramine via in vitro and in vivo experiments in a mouse model. Diphenhydramine inhibited cisplatin-induced cell death in renal proximal tubular cells. Mice administered cisplatin developed kidney injury with renal dysfunction (plasma creatinine: 0.43 ± 0.04 mg/dl vs 0.15 ± 0.01 mg/dl, p<0.01) and showed augmented oxidative stress, increased apoptosis, elevated inflammatory cytokines, and mitogen-activated protein kinases activation; however, most of these symptoms were suppressed by treatment with diphenhydramine. Further, the renal concentration of cisplatin was attenuated in diphenhydramine-treated mice (platinum content: 70.0 ± 3.3 µg/g dry kidney weight vs 53.4 ± 3.6 µg/g dry kidney weight, p<0.05). Importantly, diphenhydramine did not influence or interfere with the anti-tumor effect of cisplatin in any of the in vitro or in vivo experiments. Moreover, a retrospective clinical study of 1467 cancer patients treated with cisplatin showed that patients who had used diphenhydramine exhibited less acute kidney injury than patients who had not used diphenhydramine (6.1 % vs 22.4 %, p<0.05). Thus, diphenhydramine demonstrated efficacy as a novel preventive medicine against cisplatin-induced nephrotoxicity. |
| キーワード |
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|
主題 |
cisplatin |
| キーワード |
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主題 |
nephrotoxicity |
| キーワード |
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|
主題 |
diphenhydramine |
| 書誌情報 |
en : Kidney International
巻 99,
号 4,
p. 885-899,
発行日 2020-12-09
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00852538 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710996 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11629608 |
| 出版者 |
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|
出版者 |
Elsevier |
| 出版者 |
|
|
出版者 |
International Society of Nephrology |
| 権利情報 |
|
|
権利情報 |
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| EID |
|
|
識別子 |
372231 |
| 言語 |
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|
言語 |
eng |
kint_99_4_885.pdf (1.18 MB)
