WEKO3
アイテム
Impact of sidedness of colorectal cancer on tumor immunity
| 名前 / ファイル | ライセンス | アクション |
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pone_15_10_e0240408.pdf (1.04 MB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||||||||||||||||||||||||||||||||||
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| 公開日 | 2020-11-02 | |||||||||||||||||||||||||||||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||||||||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0240408 | |||||||||||||||||||||||||||||||||||||||||||||||
| 関連名称 | 10.1371/journal.pone.0240408 | |||||||||||||||||||||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||||||||||||||
| タイトル | Impact of sidedness of colorectal cancer on tumor immunity | |||||||||||||||||||||||||||||||||||||||||||||||
| タイトル別表記 | ||||||||||||||||||||||||||||||||||||||||||||||||
| その他のタイトル | Sidedness of CRC on tumor immunity | |||||||||||||||||||||||||||||||||||||||||||||||
| 著者 |
髙須, 千絵
× 髙須, 千絵
WEKO
517
× 西, 正暁
WEKO
699
× 吉川, 幸造
WEKO
294
× 徳永, 卓哉
WEKO
621
× 柏原, 秀也
WEKO
791
× 良元, 俊昭
WEKO
886
× 島田, 光生
WEKO
1253
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| 抄録 | ||||||||||||||||||||||||||||||||||||||||||||||||
| 内容記述 | Background Clinical and molecular characteristics differ between right-sided and left-sided colorectal cancer (CRC). This study aimed to clarify the correlation between CRC sidedness and tumor immunity. Methods A total of 102 patients who underwent curative colectomy for stage II/III CRC were included in this study. The expression of programmed cell death (PD)-1, PD1-ligand 1 (PD-L1), forkhead box P3 (Foxp3), transforming growth factor (TGF)-β, and indoleamine-pyrrole 2,3-dioxygenase (IDO) were examined using immunohistochemistry and the relationships between sidedness and several prognostic factors were examined. Results Clinicopathological factors were not significantly different between right- and left-sided CRC. The tumor immunity-related molecule PD-L1 was more highly expressed in right-sided than in left-sided CRC (62.9% vs. 30.6%, p<0.01). No significant difference was found in overall survival (OS) and disease-free survival (DFS) by sidedness. PD-1 and Foxp3 expression were significant prognostic factors for OS. Lymph node metastasis (N), lymphatic invasion (ly), and PD-L1 expression were significant prognostic factors for DFS. In right-sided CRC, IDO-positive patients had a poor OS (p<0.05), and IDO was the only independent prognostic indicator for OS. N and venous invasion were identified as independent prognostic indicators for DFS. In left-sided CRC, univariate analysis identified PD-1, PD-L1, and Foxp3 expression as significant predictors of poor OS. Multivariate analysis confirmed PD-L1 expression as an independent prognostic indicator. N, ly, and PD-L1 expression levels were identified as significant predictors of poor DFS. Conclusions The prognostic factors were IDO in right-sided CRC and PD-L1 and Foxp3 in left-sided CRC. These findings indicated that tumor immunity might play different roles depending upon sidedness. Tumor location may be an important factor to consider when assessing immune response and therapeutic decisions in CRC patients. |
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| 書誌情報 |
en : PLOS ONE 巻 15, 号 10, p. e0240408, 発行日 2020-10-12 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||||||||||||||
| 収録物識別子 | 19326203 | |||||||||||||||||||||||||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||||||||||||||||||||||||
| 出版者 | PLOS | |||||||||||||||||||||||||||||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||||||||||||||||||||||||||||
| 権利情報 | © 2020 Takasu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||||||||||||||||||||||||||||||
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| 識別子 | 377017 | |||||||||||||||||||||||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||||||||||||||||||||||
