| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-16 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1242/jcs.251314 |
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|
関連名称 |
10.1242/jcs.251314 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit |
| 著者 |
常松, 貴明
新垣, 理恵子
カワイ, ヒデヒコ
Ruppert, Jan
常山, 幸一
石丸, 直澄
Earnshaw, William C.
Pagano, Michele
工藤, 保誠
|
| 抄録 |
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内容記述 |
During mitosis, the chromosomal passenger complex (CPC) ensures the faithful transmission of the genome. The CPC is composed of the enzymatic component Aurora B (AURKB) and the three regulatory and targeting components borealin, INCENP, and survivin (also known as BIRC5). Although the CPC is known to be involved in diverse mitotic events, it is still unclear how CPC function terminates after mitosis. Here we show that borealin is ubiquitylated by the anaphase promoting complex/cyclosome (APC/C) and its cofactor Cdh1 (also known as FZR1) and is subsequently degraded in G1 phase. Cdh1 binds to regions within the N terminus of borealin that act as a non-canonical degron. Aurora B has also been shown previously to be degraded by the APC/CCdh1 from late mitosis to G1. Indeed, Cdh1 depletion sustains an Aurora B activity with stable levels of borealin and Aurora B throughout the cell cycle, and causes reduced efficiency of DNA replication after release from serum starvation. Notably, inhibition of Aurora B kinase activity improves the efficiency of DNA replication in Cdh1-depleted cells. We thus propose that APC/CCdh1 terminates CPC activity upon mitotic exit and thereby contributes to proper control of DNA replication. |
| キーワード |
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|
主題 |
Chromosome passenger complex |
| キーワード |
|
|
主題 |
Borealin |
| キーワード |
|
|
主題 |
Aurora B |
| キーワード |
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|
主題 |
Ubiquitylation |
| キーワード |
|
|
主題 |
APC/CCdh1 |
| 書誌情報 |
en : Journal of Cell Science
巻 133,
号 18,
p. jcs251314,
発行日 2020-09-15
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00219533 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14779137 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00694823 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11720335 |
| 出版者 |
|
|
出版者 |
The Company of Biologists |
| 権利情報 |
|
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| EID |
|
|
識別子 |
371986 |
| 言語 |
|
|
言語 |
eng |
jcs_133_18_jcs251314.pdf (8.2 MB)
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