| Item type |
文献 / Documents(1) |
| 公開日 |
2020-11-18 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2152/jmi.67.311 |
|
|
言語 |
ja |
|
|
関連名称 |
10.2152/jmi.67.311 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells |
|
言語 |
en |
| タイトル別表記 |
|
|
その他のタイトル |
INCS suppresses H1R gene expression |
|
言語 |
en |
| 著者 |
北村, 嘉章
神村, 盛一郎
藤井, 達也
水口, 博之
ナイトウ, ケイスケ
近藤, 英司
松田, 和徳
東, 貴弘
佐藤, 豪
福井, 裕行
武田, 憲昭
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The purpose of this study is to examine the effect of intranasal corticosteroid (INCS) administration on histamine H1 receptor (H1R) gene expression in the nasal mucosa of healthy participants and the effects of dexamethasone on basal and histamine-induced H1R mRNA expression, and histamine-induced phosphorylation of extracellular signal-regulated kinase (ERK) in HeLa cells. Sixteen healthy participants were given INCS once daily for a week. After pretreatment of dexamethasone, HeLa cells were treated with histamine. Levels of H1R mRNA and phosphorylation of ERK were measured using real time PCR and immunoblot analysis, respectively. Levels of H1R mRNA in the nasal mucosa of healthy participants receiving INCS was significantly decreased. Dexamethasone suppressed basal levels of H1R mRNA, and histamine-induced up-regulation of H1R mRNA and ERK phosphorylation in HeLa cells. These data suggested that corticosteroid inhibited both basal transcription and histamine-induced transcriptional activation of H1R through its suppression of ERK phosphorylation in the signaling pathway involved in H1R gene transcription. It is further suggested that pre-seasonal prophylactic administration of INCS suppresses both basal and pollen-induced upregulation of H1R gene expression in the nasal mucosa of patients with pollinosis, leading to prevention of the exacerbation of nasal symptoms during peak pollen season. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
corticosteroids |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
extracellular signal-regulated kinase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
healthy participants |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
histamine H1 receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
intranasal administration |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 67,
号 3-4,
p. 311-314,
発行日 2020-08
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
|
言語 |
en |
| EID |
|
|
識別子 |
373460 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jmi_67_3-4_311.pdf (509 KB)
