| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-18 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.5551/jat.35592 |
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関連名称 |
10.5551/jat.35592 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Skin Autofluorescence is Associated with Early-stage Atherosclerosis in Patients with Type 1 Diabetes |
| タイトル別表記 |
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その他のタイトル |
Skin Autofluorescence Associated with IMT |
| 著者 |
オサワ, サエコ
カタカミ, ナオト
黒田, 暁生
タカハラ, ミツヨシ
サカモト, フミエ
カワモリ, ダン
マツオカ, タカアキ
松久, 宗英
シモムラ, イチロウ
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| 抄録 |
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内容記述 |
Aim: Accumulation level of fluorescent advanced glycation end products (AGEs) in the skin can be measured non-invasively as skin autofluorescence (skin AF) by autofluorescence reader. The aim of this study was to assess possible associations between skin AF and diabetic complications, especially early-stage atherosclerosis, in Japanese type 1 diabetic patients.
Methods: Skin AF was measured by AGE reader® in 105 Japanese type 1 diabetic patients (34 men and 71 women, aged 37.4±12.4 years (±SD)) and 23 age-matched healthy non-diabetic subjects. Ultrasonic carotid intima-media thickness (IMT), ankle-brachial index (ABI), and brachial ankle pulse wave velocity (baPWV) were evaluated as indices of early-stage diabetic macroangiopathy. Urinary albumin-to-creatinine ratio (UACR), the coefficient of variation of R-R intervals (CVR-R), and presence of retinopathy were also evaluated.
Results: Skin AF values were significantly higher in type 1 diabetic patients than in healthy controls (2.07±0.50 (mean±SD) and 1.90±0.26, respectively, p=0.024). Skin AF was associated with carotid IMT (r=0.446, p＜0.001) and baPWV (r=0.450, p＜0.001), but not with ABI (r=－0.019, p=0.8488). Notably, skin AF was an independent risk factor for IMT thickening. Similarly, skin AF was associated with log (UACR) (r=0.194, p=0.049) and was an independent risk factor for UACR. Furthermore, skin AF values were significantly higher in patients with diabetic retinopathy than in those without (2.21±0.08 and 1.97±0.06, respectively, p=0.020).
Conclusions: Skin AF was significantly associated with the presence and/or severity of diabetic complications and was an independent risk factor for carotid atherosclerosis. |
| キーワード |
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主題 |
Advanced glycation end products (AGEs) |
| キーワード |
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主題 |
Skin autofluorescence |
| キーワード |
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主題 |
Carotid intima-media thickness |
| キーワード |
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主題 |
Type 1 diabetes |
| 書誌情報 |
en : Journal of Atherosclerosis and Thrombosis
巻 24,
号 3,
p. 312-326,
発行日 2017-03-01
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
18803873 |
| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13403478 |
| 出版者 |
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出版者 |
Japan Atherosclerosis Society |
| 権利情報 |
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|
権利情報 |
Copyright©2017 Japan Atherosclerosis SocietyThis article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. |
| EID |
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|
識別子 |
320429 |
| 言語 |
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|
言語 |
eng |
jat_24_3_312.pdf (355 KB)
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