| Item type |
文献 / Documents(1) |
| 公開日 |
2021-03-02 |
| アクセス権 |
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|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1111/jdi.13047 |
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関連名称 |
10.1111/jdi.13047 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice |
| タイトル別表記 |
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その他のタイトル |
Macrophage HIF-1α increases liver tumor |
| 著者 |
タキカワ, アキコ
ウスイ, イサオ
フジサカ, シホ
常山, 幸一
オカベ, ケイスケ
ナカガワ, タカシ
Nawaz, Allah
カド, トモノブ
ジョウジマ, テルオ
アソウ, ヨシマサ
ハヤカワ, ヨシヒロ
ヤギ, クニキミ
トベ, カズユキ
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| 抄録 |
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内容記述 |
Aims/Introduction: Chronic inflammation of the liver is often observed with obesity or type 2 diabetes. In these pathological conditions, the immunological cells, such as macrophages, play important roles in the development or growth of liver cancer. Recently, it was reported that hypoxia‐inducible factor‐1α (HIF‐1α) is a key molecule for the acquisition of inflammatory M1 polarity of macrophages. In the present study, we examined the effects of altered macrophage polarity on obesity‐ and diabetes‐associated liver cancer using macrophage‐specific HIF‐1α knockout (KO) mice.
Materials and Methods: To induce liver cancer in the mice, diethylnitrosamine, a chemical carcinogen, was used. Both KO mice and wild‐type littermates were fed either a high‐fat diet (HFD) or normal chow. They were mainly analyzed 6 months after HFD feeding.
Results: Development of liver cancer after HFD feeding was 45% less in KO mice than in wild‐type littermates mice. Phosphorylation of extracellular signal‐regulated kinase 2 was also lower in the liver of KO mice. Those effects of HIF‐1α deletion in macrophages were not observed in normal chow‐fed mice. Furthermore, the size of liver tumors did not differ between KO and wild‐type littermates mice, even those on a HFD. These results suggest that the activation of macrophage HIF‐1α by HFD is involved not in the growth, but in the development of liver cancer with the enhanced oncogenic extracellular signal‐regulated kinase 2 signaling in hepatocytes.
Conclusions: The activation of macrophage HIF‐1α might play important roles in the development of liver cancer associated with diet‐induced obesity and diabetes. |
| キーワード |
|
|
主題 |
Hypoxia-inducible factor-1α |
| キーワード |
|
|
主題 |
Liver cancer |
| キーワード |
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|
主題 |
Macrophage |
| 書誌情報 |
en : Journal of Diabetes Investigation
巻 10,
号 6,
p. 1411-1418,
発行日 2019-03-21
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20401124 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12488319 |
| 出版者 |
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|
出版者 |
Asian Association for the Study of Diabetes |
| 出版者 |
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|
出版者 |
John Wiley & Sons |
| 権利情報 |
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|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| EID |
|
|
識別子 |
355875 |
| 言語 |
|
|
言語 |
eng |
jdi_10_6_1411.pdf (1.32 MB)
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