| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-19 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1093/jrr/rry091 |
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|
関連名称 |
10.1093/jrr/rry091 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Clinical outcomes of hypofractionated image-guided multifocal irradiation using volumetric-modulated arc therapy for brain metastases |
| タイトル別表記 |
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その他のタイトル |
HFIGMI–VMAT for brain metastases |
| 著者 |
古谷, 俊介
生島, 仁史
佐々木, 幹治
外礒, 千智
タカハシ, アヤカ
久保, 亜貴子
川中, 崇
原田, 雅史
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| 抄録 |
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内容記述 |
Volumetric-modulated arc therapy (VMAT) can be used to design hypofractionated radiotherapy treatment plans for multiple brain metastases. The purpose of this study was to evaluate treatment outcomes of hypofractionated image-guided multifocal irradiation using VMAT (HFIGMI–VMAT) for brain metastases. From July 2012 to December 2016, 67 consecutive patients with 601 brain metastases were treated with HFIGMI–VMAT at our institution. The prescribed dose was 50 Gy to a 95% volume of the planning target volume in 10 fractions. Fifty-five of the 67 patients had non-small-cell lung cancer, and the remaining 12 had other types of cancer. The median number of brain metastases was five, and the median maximum diameter was 1.2 cm. The median duration of follow-up was 12.0 months (range, 1.9–44.8 months), and the median survival time 18.7 months. Four patients with six lesions had local recurrences. The local control rate in the 64 assessed patients was 98.4% and 95.3% at 6 and 12 months, respectively (three died before assessment). The local control rate for the 572 assessed lesions was 99.8% and 99.3% at 6 and 12 months, respectively. Thirty-nine patients developed distant brain metastases, the distant brain control rate being 59.7% and 40.5% at 6 and 12 months, respectively. Acute toxicities were generally mild (Grade 1–2). Three patients (4.5%) developed radiation necrosis requiring corticosteroid therapy. The HFIGMI–VMAT technique with flat dose delivery was well tolerated and achieved excellent local control. This technique is a promising treatment option for patients with multiple and large brain metastases. |
| キーワード |
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|
主題 |
hypofractionated radiotherapy |
| キーワード |
|
|
主題 |
volumetric-modulated arc therapy |
| キーワード |
|
|
主題 |
brain metastases |
| キーワード |
|
|
主題 |
linear accelerator |
| 書誌情報 |
en : Journal of Radiation Research
巻 60,
号 1,
p. 134-141,
発行日 2018-11-17
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13499157 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00705792 |
| 出版者 |
|
|
出版者 |
Oxford University Press |
| 出版者 |
|
|
出版者 |
The Japanese Radiation Research Society |
| 出版者 |
|
|
出版者 |
Japanese Society for Radiation Oncology |
| 権利情報 |
|
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| EID |
|
|
識別子 |
348679 |
| 言語 |
|
|
言語 |
eng |
jrr_60_1_134.pdf (298 KB)
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