| Item type |
文献 / Documents(1) |
| 公開日 |
2021-02-19 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/jrr/rrv030 |
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言語 |
ja |
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|
関連名称 |
10.1093/jrr/rrv030 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice |
|
言語 |
en |
| タイトル別表記 |
|
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その他のタイトル |
Stress and radiation hematopoietic toxicity |
|
言語 |
en |
| 著者 |
Wang, Bing
タナカ, カオル
カツベ, タカノリ
ニノミヤ, ヤスハル
Vares, Guillaume
Liu, Qiang
森田, 明典
ナカジマ, テツオ
ネノイ, ミツル
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility of Trp53 -heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type (Trp53 wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow erythrocytes using a mouse restraint model. Five-week-old male Trp53 wt C57BL/6J mice were restrained 6 h per day for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS. CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53 wt mice. |
|
言語 |
en |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chronic restraint-induced stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
total-body irradiation |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
peripheral blood hemogram |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone marrow micronucleated erythrocytes |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
mouse restraint model |
| 書誌情報 |
en : Journal of Radiation Research
巻 56,
号 5,
p. 760-767,
発行日 2015-06-04
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13499157 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00705792 |
| 出版者 |
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|
出版者 |
Oxford University Press |
|
言語 |
en |
| 出版者 |
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|
出版者 |
The Japanese Radiation Research Society |
|
言語 |
en |
| 出版者 |
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出版者 |
Japanese Society for Radiation Oncology |
|
言語 |
en |
| 権利情報 |
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|
言語 |
en |
|
権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| EID |
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|
識別子 |
295312 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
jrr_56_5_760.pdf (395 KB)
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