| Item type |
文献 / Documents(1) |
| 公開日 |
2021-03-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ma11101993 |
|
|
言語 |
ja |
|
|
関連名称 |
10.3390/ma11101993 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and β-Tricalcium Phosphate Bone Substitutes |
|
言語 |
en |
| 著者 |
イシカワ, クニオ
宮本, 洋二
ツチダ, アキラ
林, 幸壱朗
ツル, カンジ
大江, 剛
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone®), carbonate apatite (CO3Ap; Cytrans®), and β-tricalcium phosphate (β-TCP; Cerasorb®), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone® (HAp) and Cerasorb® (β-TCP) were porous, whereas Cytrans® (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone® (HAp), Cytrans® (CO3Ap), and Cerasorb® (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m2/g, 18.2 m2/g, and 1.0 m2/g, respectively. These values are consistent with the fact that both Neobone® (HAp) and Cerasorb® (β-TCP) are sintered ceramics, whereas Cytrans® (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship’s lacunae was fastest in CO3Ap (Cytrans®), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb®). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship’s lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans®) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans®) was confirmed. β-TCP (Cerasorb®) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans®) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone. |
|
言語 |
en |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
carbonate apatite |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hydroxyapatite |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
β-tricalcium phosphate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
artificial bone substitute |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
crystallite size |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dissolution rate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hybrid dog |
| 書誌情報 |
en : Materials
巻 11,
号 10,
p. 1993,
発行日 2018-10-16
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
19961944 |
| 出版者 |
|
|
出版者 |
MDPI |
|
言語 |
en |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
348015 |
|
識別子タイプ |
URI |
| 言語 |
|
|
言語 |
eng |
materials_11_10_1993.pdf (4.53 MB)
.png)
