| Item type |
文献 / Documents(1) |
| 公開日 |
2021-03-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
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|
関連識別子 |
https://doi.org/10.3390/molecules22040533 |
|
|
関連名称 |
10.3390/molecules22040533 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Artesunate Enhances the Cytotoxicity of 5-Aminolevulinic Acid-Based Sonodynamic Therapy against Mouse Mammary Tumor Cells In Vitro |
| 著者 |
オオサキ, トモヒロ
宇都, 義浩
イシヅカ, マサヒロ
タナカ, トオル
ヤマナカ, ノブヤス
クラハシ, ツカサ
アズマ, カズオ
ムラハタ, ユウスケ
ツカ, タケシ
イトウ, ノリヒコ
イマガワ, トモヒロ
オカモト, ヨシハル
|
| 抄録 |
|
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内容記述 |
Sonodynamic therapy (SDT) kills tumor cells through the synergistic effects of ultrasound (US) and a sonosensitizer agent. 5-Aminolevulinic acid (5-ALA) has been used as a sonodynamic sensitizer for cancer treatment. However, studies have shown that 5-ALA-based SDT has limited efficacy against malignant tumors. In this study, we examined whether artesunate (ART) could enhance the cytotoxicity of 5-ALA-based SDT against mouse mammary tumor (EMT-6) cells in vitro. In the ART, ART + US, ART + 5-ALA, and ART + 5-ALA + US groups, the cell survival rate correlated with ART concentration, and decreased with increasing concentrations of ART. Morphologically, many apoptotic and necrotic cells were observed in the ART + 5-ALA + US group. The percentage of reactive oxygen species-positive cells in the ART + 5-ALA + US group was also significantly higher than that in the 5-ALA group (p = 0.0228), and the cell death induced by ART + 5-ALA + US could be inhibited by the antioxidant N-acetylcysteine. These results show that ART offers great potential in enhancing the efficacy of 5-ALA-based SDT for the treatment of cancer. However, these results are only based on in vitro studies, and further in vivo studies are required. |
| キーワード |
|
|
主題 |
5-aminolevulinic acid |
| キーワード |
|
|
主題 |
artesunate |
| キーワード |
|
|
主題 |
breast cancer |
| キーワード |
|
|
主題 |
sonodynamic therapy |
| キーワード |
|
|
主題 |
ultrasound |
| 書誌情報 |
en : Molecules
巻 22,
号 4,
p. 533,
発行日 2017-03-27
|
| 収録物ID |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14203049 |
| 出版者 |
|
|
出版者 |
MDPI |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
323602 |
| 言語 |
|
|
言語 |
eng |
molecules_22_4_533.pdf (2.83 MB)
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